ArticleClinica chimica acta; international journal of clinical chemistry2017
Accuracy-based proficiency testing for testosterone measurements with immunoassays and liquid chromatography-mass spectrometry.
Article in Clinica chimica acta; international journal of clinical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Highly specific ID-UHPLC-MS/MS method for analyzing polar and non-polar steroid hormones.Analytical and bioanalytical chemistry · 2026Article
- Evaluation of the Siemens Healthineers Atellica TSTII testosterone assay in the CDC HoSt-TT program.The Journal of clinical endocrinology and metabolism · 2026Article
- Clinical Usefulness of Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry Method for Low Serum Testosterone Measurement.Annals of laboratory medicine · 2023Article
- Possible testosterone redundancy for 5α-dihydrotestosterone in the masculinization of mouse external genitalia.Experimental animals · 2022Article
- Effects of testosterone treatment on clitoral haemodynamics in women with sexual dysfunction.Journal of endocrinological investigation · 2021Observational
- Using mass spectrometry to overcome the longstanding inaccuracy of a commercially-available clinical testosterone immunoassay.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2021Article
- Measurement of Serum Testosterone in Nondiabetic Young Obese Men: Comparison of Direct Immunoassay to Liquid Chromatography-Tandem Mass Spectrometry.Biomolecules · 2020Article
- Androgens by immunoassay and mass spectrometry in children with 46,XY disorder of sex development.Endocrine connections · 2020Article
- Testosterone suppression in the treatment of recurrent or metastatic prostate cancer - A Canadian consensus statement.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundAccurate testosterone measurements are needed to correctly diagnose and treat patients. Proficiency Testing (PT) programs using modified specimens for testing can be limited because of matrix effects and usage of non-reference measurement procedure (RMP)-defined targets for evaluation. Accuracy-based PT can overcome such limitations; however, there is a lack of information on accuracy-based PT and feasibility of its implementation in evaluation for testosterone measurements.
methodsUnaltered, single-donor human serum from 2 male and 2 female adult donors were analyzed for testosterone by 142 NYSDH-certified clinical laboratories using 16 immunoassays and LC-MS/MS methods. Testosterone target values were determined using an RMP.
resultsThe testosterone target concentrations for the 4 specimens were 15.5, 30.0, 402 and 498ng/dl. The biases ranged from -17.8% to 73.1%, 3.1% to 21.3%, -24.8% to 8.6%, and -22.1% to 6.8% for the 4 specimens, respectively. Using a total error target of ±25.1%, which was calculated using the minimum allowable bias and imprecision, 73% of participating laboratories had ≥3 of the 4 results within these limits.
conclusionsThe variability in total testosterone measurements can affect clinical decisions. Accuracy-based PT can significantly contribute to improving testosterone testing by providing reliable data on accuracy in patient care to laboratories, assay manufacturers, and standardization programs.
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