ArticleHealth and quality of life outcomes2017
Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea.
Article in Health and quality of life outcomes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Association between obstructive sleep apnea and erectile dysfunction: a systematic review and meta-analysis.International journal of impotence research · 2018Pooled it
- Receipt of glucagon-like peptide-1 receptor agonists among rural patients with obstructive sleep apnea and excess weight.Annals of the American Thoracic Society · 2026Article
- Excessive daytime sleepiness and mortality: racial/ethnic variations in a large cohort of veterans.Sleep medicine · 2025Article
- Assessment of Comprehensive Patient-Reported Outcomes Before and After CPAP Therapy in Obstructive Sleep Apnea.Biomedicines · 2025Article
- Article
- Fatigue is distinct from sleepiness and negatively impacts individuals living with obstructive sleep apnea (OSA): results from qualitative research of individuals with OSA.Health and quality of life outcomes · 2025Article
- Age modulates the predictive value of self-reported sleepiness for all-cause mortality risk: insights from a comprehensive national database of veterans.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Recent advances in managing obstructive sleep apnea.World journal of clinical cases · 2024Article
- A new approach to streamline obstructive sleep apnea therapy access using peripheral arterial tone-based home sleep test devices.Frontiers in sleep · 2023Article
- Sleep Apnea and Cardiovascular Risk in Patients with Prediabetes and Type 2 Diabetes.Nutrients · 2022Review
- Prevalence and Characteristics of Erectile Dysfunction in Obstructive Sleep Apnea Patients.Frontiers in endocrinology · 2022Article
- Demographic, clinical, and biomarker predictors of apnea-hypopnea index from polysomnography in Midwestern sleep clinic patients.Sleep & breathing = Schlaf & Atmung · 2021Article
- Technologic advances in the assessment and management of obstructive sleep apnoea beyond the apnoea-hypopnoea index: a narrative review.Journal of thoracic disease · 2020Review
- Article
- Fatigue, Sleep, and Autoimmune and Related Disorders.Frontiers in immunology · 2019Review
- Quality of life in obstructive sleep apnea is related to female gender and comorbid insomnia.Sleep & breathing = Schlaf & Atmung · 2018Article
- Factors associated with excessive daytime sleepiness in informal drivers of buses on a high-altitude road.Sleep science (Sao Paulo, Brazil)Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundIn those with symptoms indicative of obstructive sleep apnea (OSA), respiratory-specific health-related quality of life (HRQL) may be an important patient-centered outcome. The aim of this study was to assess the associations between sleepiness, fatigue, and impaired general and respiratory-specific HRQL among persons with suspected OSA.
methodsWe evaluated military veterans consecutively referred for suspected OSA with sleep studies yielding apnea-hypopnea index (AHI) values. They also completed the sleepiness (Epworth Sleepiness Scale [ESS]), and fatigue (Fatigue Severity Scale [FSS]) questionnaires, as well as two HRQL instruments (the generic Short-Form SF-12v2 yielding the Physical Component Scale [PCS] and the respiratory-specific Airways Questionnaire [AQ]-20R). Multiple linear regression tested the associations between ESS and FSS (standardized as Z scores for scaling comparability) with AQ-20R, accounting for AHI, SF-12v2-PCS and comorbid respiratory conditions other than OSA.
resultsWe studied 1578 veterans (median age 61.1 [IQR 16.8] years; 93.9% males). Of these, 823 (52%) met AHI criteria for moderate to severe OSA (AHI ≥15/h). The majority reported excessive daytime sleepiness (53%; median ESS 11 [IQR 9]) or fatigue (61%; median FSS 42 [IQR 23]). The median AQ-20R was 4 [IQR 1-8]. Controlling for AHI, SF-12v2-PCS, respiratory co-morbid conditions, body mass index, and demographics, both ESS and FSS were significantly associated with poorer AQ-20R: for each; ESS, 1.6 points (95% CI 1.4-1.9), and for FSS, 2.5 points (95% CI, 2.3-2.7).
conclusionsGreater daytime sleepiness and fatigue are associated with poorer respiratory-specific HRQL, over and above the effects of OSA, respiratory comorbidity, and generic physical HRQL.
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