ArticleBMC evolutionary biology2017
Coinfection outcome in an opportunistic pathogen depends on the inter-strain interactions.
Article in BMC evolutionary biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Review
- Identification of Opportunistic Pathogens on the Skin of Salamanders for Use as Molecular Targets of a De Novo Design of Multitarget Anti-International journal of microbiology · 2026Article
- Infections as ecosystems: community metabolic interactions in microbial pathogenesis.Infection and immunity · 2025Review
- Differential Transcriptomic Profile ofMicroorganisms · 2024Article
- Expression of key cytokines in dog macrophages infected by Leishmania tarentolae opening new avenues for the protection against Leishmania infantum.Scientific reports · 2024Article
- The Dominance of Coinfecting Parasites' Indirect Genetic Effects on Host Traits.The American naturalist · 2024Article
- Entomopathogenic pseudomonads can share an insect host with entomopathogenic nematodes and their mutualistic bacteria.The ISME journal · 2024Article
- Dynamics of co-infection in fish: A review of pathogen-host interaction and clinical outcome.Fish and shellfish immunology reports · 2023Article
- Intra-hostMicrobiology spectrum · 2023Article
- Coinfection with chytrid genotypes drives divergent infection dynamics reflecting regional distribution patterns.Communications biology · 2023Article
- Article
- Cohabitation ofFrontiers in cellular and infection microbiology · 2023Article
- Epidermal Microbiomes of Leopard Sharks (Microorganisms · 2022Article
- Interspecies and Intrastrain Interplay amongMicroorganisms · 2022Review
- Assessing rates of parasite coinfection and spatiotemporal strain variation via metabarcoding: Insights for the conservation of European turtle doves Streptopelia turtur.Molecular ecology · 2022Article
- Antibiotic treatment increases yellowness of carotenoid feather coloration in male greenfinches (Chloris chloris).Scientific reports · 2021Article
- Dual RNAseq highlights the kinetics of skin microbiome and fish host responsiveness to bacterial infection.Animal microbiome · 2021Article
- Cooperative Interaction ofInternational journal of molecular sciences · 2020Article
- Article
- Occurrence of multiple genotype infection caused by Leishmania infantum in naturally infected dogs.PLoS neglected tropical diseases · 2020Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn nature, organisms are commonly coinfected by two or more parasite strains, which has been shown to influence disease virulence. Yet, the effects of coinfections of environmental opportunistic pathogens on disease outcome are still poorly known, although as host-generalists they are highly likely to participate in coinfections. We asked whether coinfection with conspecific opportunistic strains leads to changes in virulence, and if these changes are associated with bacterial growth or interference competition. We infected zebra fish (Danio rerio) with three geographically and/or temporally distant environmental opportunist Flavobacterium columnare strains in single and in coinfection. Growth of the strains was studied in single and in co-cultures in liquid medium, and interference competition (growth-inhibiting ability) on agar.
resultsThe individual strains differed in their virulence, growth and ability for interference competition. Number of coinfecting strains significantly influenced the virulence of infection, with three-strain coinfection differing from the two-strain and single infections. Differences in virulence seemed to associate with the identity of the coinfecting bacterial strains, and their pairwise interactions. This indicates that benefits of competitive ability (production of growth-inhibiting compounds) for virulence are highest when multiple strains co-occur, whereas the high virulence in coinfection may be independent from in vitro bacterial growth.
conclusionsIntraspecific competition can lead to plastic increase in virulence, likely caused by faster utilization of host resources stimulated by the competitive interactions between the strains. However, disease outcome depends both on the characteristics of individual strains and their interactions. Our results highlight the importance of strain interactions in disease dynamics in environments where various pathogen genotypes co-occur.
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