ArticleRedox report : communications in free radical research2017
The role of the saliva antioxidant barrier to reactive oxygen species with regard to caries development.
Article in Redox report : communications in free radical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Obesity and Dental Caries: A State-of-the-Art Review of Shared Risk Factors, Biological Mechanisms and Current Evidence.Medical sciences (Basel, Switzerland) · 2026Review
- Association between number of teeth and oxidative balance score in Korean adults: a population-based study.Korean journal of community nutrition · 2026Article
- Polymorphisms in SOD2 and SOD3 Genes are Associated with Dental Caries in Primary Dentition of Brazilian Children.Biochemical genetics · 2026Article
- Pre-post intervention changes in salivary biomarkers after dental treatment in children with caries: A systematic review and meta-analysis.Journal of clinical and experimental dentistry · 2025Review
- Dental Caries and Salivary Oxidative Stress: Global Scientific Research Landscape.Antioxidants (Basel, Switzerland) · 2023Review
- Comparison of oral cavity protein abundance among caries-free and caries-affected individuals-a systematic review and meta-analysis.Frontiers in oral health · 2023Review
- Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review.Metabolites · 2022Review
- Redefining the Cut-Off Ranges for TSH Based on the Clinical Picture, Results of Neuroimaging and Laboratory Tests in Unsupervised Cluster Analysis as Individualized Diagnosis of Early Schizophrenia.Journal of personalized medicine · 2022Article
- Article
- Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children's Saliva.Oxidative medicine and cellular longevity · 2020Article
- The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products.International journal of molecular sciences · 2019Review
- Comparison of Salivary Antioxidants in Children with Primary Tooth Abscesses before and after Treatment in Comparison with Healthy SubjectsAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Relationship between Pyruvate Kinase Activity and Cariogenic Biofilm Formation inFrontiers in microbiology · 2017Article
- Salivary Vitamin D and Glutathione Peroxidase as Biomarkers for Caries in Children.Contemporary clinical dentistryArticle
- Correlation of Carbonic Anhydrase VI Enzyme, Total Proteins, Antioxidant Levels of Saliva and Dental Caries in Caries-Free and Caries-Active Children - A Case-Control Study.Contemporary clinical dentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to evaluate the role of the antioxidant barrier in the saliva of children with caries, and its impact on the colonization of cariogenic bacteria.
methodsThis is a cross-sectional study of 81 children aged 1-5 years. Antioxidant levels and salivary bacterial profiles were measured. Patients were divided into two groups as follows: initial stage decay, termed non-cavitated (1-2 in International Caries Detection and Assessment System (ICDAS)), and extensive decay, termed cavitated lesions (5-6 in ICDAS). The control group includes children without caries.
resultsThe linear regression model demonstrated that the GSH, GSSG, GSH/GSSG, and total antioxidant capacity levels are influenced (P < 0.05) by: the stage of caries and the dominant bacterial strain. Compared with the other groups (P < 0.001), the highest antioxidant parameters were recorded in the saliva of patients with cavitated lesions. DISCUSSION: Our results indicate that the high levels of antioxidants in saliva increase significantly in children in line with the salivary cariogenic bacterial profiles and caries progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.