ArticleNature immunology2017
Epigenetic landscapes reveal transcription factors that regulate CD8
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 160 papers.
0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
160 citing papers in PubMed, 254 citations in OpenAlex.
- Identification of a systemic lupus erythematosus disease signature in resting naive B cells.The Journal of clinical investigation · 2026Article
- Progenitor T cells drive chronic pulmonary type 2 inflammation.Nature immunology · 2026Article
- The ADAP-TRIM21-ZEB2 axis regulates CD8iScience · 2026Article
- Unique CD8bioRxiv : the preprint server for biology · 2026Article
- A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state.Immunity · 2026Article
- Two Faces of NFAT Transcription Factors in LymphocytesBiomolecules · 2026Review
- Pharmacological potential of the histone demethylase inhibitor GSK-J4 in mitigating NF-κB-mediated inflammatory cascades associated with autoimmune disorders.Inflammopharmacology · 2026Article
- Multiomic Profiling Reveals the Regulation of Many Immune-Related Genes by PU.1 in Porcine Alveolar Macrophages.Animals : an open access journal from MDPI · 2026Article
- Review
- Hormonal rewiring of immunity during dietary restriction ensures host defense and systemic glucose conservation.Immunity · 2026Article
- Optimal transport fate mapping resolves T cell differentiation dynamics across tissues.bioRxiv : the preprint server for biology · 2026Article
- Selective Glucocorticoid Receptor Modulators of Immune Checkpoint Function.bioRxiv : the preprint server for biology · 2026Article
- Age-independent and targetable transcription factor networks regulating CD8Cell reports · 2026Article
- Clinical immunology in chromatinopathies: a scoping review.Frontiers in immunology · 2026Article
- Transcriptional and epigenetic control of human naïve CD8Frontiers in immunology · 2026Article
- Article
- Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV-Specific CD8European journal of immunology · 2025Article
- Cisformer: a scalable cross-modality generation framework for decoding transcriptional regulation at single-cell resolution.Genome biology · 2025Article
- The transcription factor BATF pioneers the differentiation program of effector CD8Cell reports · 2025Article
- H2A.Z primes an epigenetic landscape for memory CD8Nature communications · 2025Article
100 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
12 authors at 4 institutions in 2 countries.
Bingfei YuDivision of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Kai ZhangBioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0003-3454-7357
J Justin MilnerDivision of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Clara TomaDivision of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Runqiang ChenDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
James P Scott-BrowneDivision of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Renata M PereiraDivision of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Shane CrottyDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.ORCID 0000-0002-6484-6262
John T ChangDepartment of Medicine, University of California, San Diego, La Jolla, California, USA.
Matthew E PipkinDepartment of Immunology and Microbial Science, The Scripps Research Institute, Jupiter, Florida, USA.
Wei WangBioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California, USA.
Ananda W GoldrathDivision of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
University of California San Diego · USLa Jolla Institute for Immunology · USScripps Research Institute · USUniversidade Federal do Rio de Janeiro · BR
Funding
GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8MCenter for Mammalian Regulatory GenomicsU54HG006997 · NHGRI · LUDWIG INSTITUTE FOR CANCER RES LTD · PI REN, BING · 2012 to 2016
$14.3MSIGNAL TRANSDUCTION AND GENE INDUCTION IN T LYMPHOCYTESR01AI040127 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK, RAO, ANJANA · 1996 to 2025
$13.3MTF regulation of CD8 and CD4 T cell memory in both systemic and dermal infectionU19AI109976 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROTTY, SHANE P · 2014 to 2018
$10.5MNFAT, bZIP proteins, and transcriptional programs in lymphocytesR01AI109842 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Patrick Hogan, Anjana Rao · 2014 to 2026
$8.6MT cell maintenance: molecular mediators of the TCR-derived survival signalR01AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2006 to 2021
$6.1MRegulation of T cell immunity to viral infectionR01AI072117 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2008 to 2022
$5.4MIntegrated analysis of genetic variation and epigenomic dataR01HG009626 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, WEI · 2017 to 2025
$4.5MT cell maintenance: molecular mediators of T cell differentiation and survivalR37AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2022 to 2026
$3.0MIllumina HiSeq 2500 Sequencing SystemS10OD016262 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI RAO, ANJANA · 2013 to 2013
$600kIdentifying synergistic therapeutic targets in RA using systems biologyR21AR070310 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, WANG, WEI · 2016 to 2017
$375kNHGRI NIH HHS R01 HG009626NHGRI NIH HHS U54 HG006997NIAID NIH HHS R01 AI040127NIAID NIH HHS R01 AI067545NIAID NIH HHS R01 AI072117NIAID NIH HHS R01 AI109842NIAID NIH HHS R37 AI067545NIAID NIH HHS U19 AI109976NIAMS NIH HHS R21 AR070310NIGMS NIH HHS T32 GM007240NIH HHS S10 OD016262
Abstract
Dynamic changes in the expression of transcription factors (TFs) can influence the specification of distinct CD8
Indexed as
Epigenesis, GeneticAnimalsCD8-Positive T-LymphocytesCell DifferentiationComputational BiologyEnhancer Elements, GeneticGene Expression ProfilingHistonesImmunologic MemoryListeriosisMiceMice, Inbred C57BLReceptors, GlucocorticoidT-Lymphocyte SubsetsYY1 Transcription FactorHistonesNR3C1 protein, mouseReceptors, GlucocorticoidYy1 protein, mouseYY1 Transcription Factor
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.