Evidence map›Paper›PMID 28287639›Full record

ArticleBone marrow transplantation2017

Use of haploidentical stem cell transplantation continues to increase: the 2015 European Society for Blood and Marrow Transplant activity survey report.

J R Passweg, H Baldomero, P Bader, C Bonini, R F Duarte, C Dufour, A Gennery, N Kröger, J Kuball, F Lanza and 5 more

Registry-linked trialOpen access · hybridAbstract readMulticenter Study
In one paragraph

Article in Bone marrow transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03689907 (Assessing the Predictive Potential of Early Chimerism Analysis Following Allogeneic Stem-Cell Transplant), which is not on this map. Cited by 173 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 3 pooled it
38.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03689907 completednot on this mapstarted 2019, after this paper: background citation

Assessing the Predictive Potential of Early Chimerism Analysis Following Allogeneic Stem-Cell Transplant

TypeobservationalSponsorDartmouth-Hitchcock Medical CenterRan2019 to 2024Enrolled40ConditionsAllogeneic Stem-Cell TransplantArmsChimerism Evaluation
3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 3 syntheses or guidelines pooled it, 387 citations in OpenAlex.

  1. Pooled it
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  8. Impact of Donor Type and Melphalan Dose on Allogeneic Transplantation Outcomes for Patients with Lymphoma.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Trial
  9. Outcomes of Haploidentical Transplantation in Patients with Relapsed Multiple Myeloma: An EBMT/CIBMTR Report.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Trial
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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 9 countries.

J R PasswegEBMT Activity Survey Office, Division of Hematology, Department of Medicine, University Hospital, Basel, Switzerland.
H BaldomeroEBMT Activity Survey Office, Division of Hematology, Department of Medicine, University Hospital, Basel, Switzerland.
P BaderKlinik für Kinder- und Jugendmedizin, Klinikum der Johann-Wolfgang, Goethe-Universität, Frankfurt am Main, Germany.
C BoniniUniversità Vita-Salute San Raffaele, Milan, Italy.
R F DuarteServicio de Hematologia y Hemoterapia, Hospital Universitario Puerta de Hierro, Madrid, Spain.
C DufourHematology Unit, G.Gaslini Children's Institute, Genova, Italy.
A GenneryChildren's BMT Unit, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle-Upon-Tyne, UK.
N KrögerDepartment of Stem Cell Transplantation, University Hospital Eppendorf, Hamburg, Germany.
J KuballDepartment of Haematology, University Medical Centre, Utrecht, The Netherlands.
F LanzaUnità Operativa di Ematologia, Ospedale Civile, Ravenna, Italy.
S MontotoSt Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
A NaglerChaim Sheba Medical Center, Tel-Hashomer, Israel.
J A SnowdenSheffield Teaching Hospitals NHS Trust, Royal Hallamshire Hospital, Sheffield, UK.
J StyczynskiDepartment of Pediatric Hematology and Oncology, University Hospital, Collegium Medicum UMK, Bydgoszcz, Poland.
M MohtyDepartment of Hematology, Hospital Saint Antoine, Paris, France.
Goethe University Frankfurt · DESorbonne Université · FRSt Bartholomew's Hospital · GBUniversität Hamburg · DEUniversity Hospital of Basel · CHIstituto Giannina Gaslini · ITRoyal Hallamshire Hospital · GBRoyal Victoria Infirmary · GBSheba Medical Center · ILUniversity Medical Center Utrecht · NLVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic stem cell transplantation (HSCT) is an established procedure for many acquired and congenital disorders of the hematopoietic system. A record number of 42 171 HSCT in 37 626 patients (16 030 allogeneic (43%), 21 596 autologous (57%)) were reported by 655 centers in 48 countries in 2015. Trends include continued growth in transplant activity over the last decade, with the highest percentage increase seen in middle-income countries but the highest absolute growth in the very-high-income countries in Europe. Main indications for HSCT were myeloid malignancies 9413 (25%; 96% allogeneic), lymphoid malignancies 24 304 (67%; 20% allogeneic), solid tumors 1516 (4%; 3% allogeneic) and non-malignant disorders 2208 (6%; 90% allogeneic). Remarkable is the decreasing use of allogeneic HSCT for CLL from 504 patients in 2011 to 255 in 2015, most likely to be due to new drugs. Use of haploidentical donors for allogeneic HSCT continues to grow: 2012 in 2015, a 291% increase since 2005. Growth is seen for all diseases. In AML, haploidentical HSCT increases similarly for patients with advanced disease and for those in CR1. Both marrow and peripheral blood are used as the stem cell source for haploidentical HSCT with higher numbers reported for the latter.

Indexed as

Hematopoietic Stem Cell TransplantationRegistriesAllograftsAutograftsEuropeFemaleHumansMaleSocieties, Medical

Identifiers

PMID28287639
PMCPMC5467246
OpenAlexW2595261904

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.