ArticleNutrition & diabetes2017
Negative association between acrylamide exposure and body composition in adults: NHANES, 2003-2004.
Article in Nutrition & diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pooled it
- Lycopene ameliorates acrylamide-induced reproductive toxicity through enhancement in testicular antioxidant status and upregulation of androgen receptor expression in male Wistar rats.BMC pharmacology & toxicology · 2026Article
- Prenatal exposure to acrylamide and metabolic health at 20 years of age A biomarker-based Danish cohort study.Environment international · 2026Article
- Article
- Green Synthesized Zinc Oxide Nanoparticles Attenuate Acrylamide-Induced Cardiac Injury via Controlling Endoplasmic Reticulum Stress-Associated Apoptosis Through ATF3/CHOP/BCL2 Signaling in Rats.Biological trace element research · 2024Article
- Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the "European Human Biomonitoring Initiative" HBM4EU participating studies.Scientific reports · 2023Article
- Ultraprocessed Foods and Obesity Risk: A Critical Review of Reported Mechanisms.Advances in nutrition (Bethesda, Md.) · 2023Review
- Food contaminants and potential risk of diabetes development: A narrative review.World journal of diabetes · 2023Review
- Acrylamide and Potential Risk of Diabetes Mellitus: Effects on Human Population, Glucose Metabolism and Beta-Cell Toxicity.International journal of molecular sciences · 2022Review
- Vitamin D mediates the association between acrylamide hemoglobin biomarkers and obesity.Environmental science and pollution research international · 2022Article
- Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population.International journal of environmental research and public health · 2021Article
- The protective effects of 18β-glycyrrhetinic acid against acrylamide-induced cellular damage in diabetic rats.Environmental science and pollution research international · 2021Article
- Associations of acrylamide with non-alcoholic fatty liver disease in American adults: a nationwide cross-sectional study.Environmental health : a global access science source · 2021Article
- Obesity and endocrine-disrupting chemicals.Endocrine connections · 2021Review
- Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats.Journal of toxicologic pathology · 2020Article
- Environmental Obesogens and Their Impact on Susceptibility to Obesity: New Mechanisms and Chemicals.Endocrinology · 2020Review
- Association between acrylamide exposure and sex hormones in males: NHANES, 2003-2004.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesAcrylamide is present in mainstream cigarette smoke and in some food prepared at high temperature. Animal studies have shown that acrylamide exposure reduces body weight. Prenatal exposure to acrylamide also has been linked to reduced birth weight in human. Whether acrylamide exposure is associated with altered body compositions in adults is not clear. SUBJECTS/
methodsWe selected 3623 subjects (aged ⩾20 years) from a National Health and Nutrition Examination Survey (NHANES) in 2003-2004 to determine the relationship among hemoglobin adducts of acrylamide (HbAA), hemoglobin adducts of glycidamide (HbGA) and body composition (body measures, bioelectrical impedance analysis (BIA), dual energy x-ray absorptiometry (DXA)). Data were adjusted for potential confounding variables.
resultsThe geometric means and 95% CI concentrations of HbAA and HbGA were 60.48 (59.32-61.65) pmol/g Hb and 55.64 (54.40-56.92) pmol/g Hb, respectively. After weighting for sampling strategy, we identified that one-unit increase in natural log-HbAA, but not HbGA, was associated with reduction in body measures (body weight, body mass index (BMI), subscapular/triceps skinfold), parameters of BIA (fat-free mass, fat mass, percent body fat, total body water) and parameters of DXA (android fat mass, android percent fat, gynoid fat/lean mass, gynoid percent mass, android to gynoid ratio). Subgroup analysis showed that these associations were more evident in subjects at younger age, male gender, whites, lower education level, active smokers and those with lower BMI.
conclusionsHigher concentrations of HbAA are associated with a decrease in body composition in the US general population. Further studies are warranted to clarify this association.
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Registered trials
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