Evidence map›Paper›PMID 28287619›Full record

ArticleScientific reports2017

Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains.

Kenneth R Johnson, Cong Tian, Leona H Gagnon, Haiyan Jiang, Dalian Ding, Richard Salvi

Open access · goldAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 79 citations in OpenAlex.

  1. Honokiol-mediated reversal of cisplatin-induced transcriptomic changes in outer hair cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Article
  2. Auditory Cortex Distinguishes between Spontaneous and Sound-Evoked Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
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  8. Pharmacologic Inhibition of JAK1/2 Potentiates Aminoglycoside-Induced Ototoxicity.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026
    Article
  9. AAV-mediated exon skipping therapy for Usher syndrome, type 2A.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  10. Review
  11. Effects of Cholesterol Modulation on Cisplatin-Induced Hearing Loss.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. TNFAIP8L2 maintains hair cell function and regulates age-related hearing loss via mTORC1 signaling.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Direct Piriform-to-Auditory Cortical Projections Shape Auditory-Olfactory Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kenneth R JohnsonThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Cong TianThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Leona H GagnonThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Haiyan JiangCenter for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA.
Dalian DingCenter for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA.
Richard SalviCenter for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA.
Jackson Laboratory · USWomen & Children's Hospital of Buffalo · US

Funding

Genetics of Age-Related Hearing LossR01DC005827 · NIDCD · JACKSON LABORATORY · PI JOHNSON, KENNETH R · 2003 to 2016
$4.6M
NIDCD NIH HHS R01 DC005827
6 · The paper itself

Abstract

A single nucleotide variant (SNV) of the cadherin 23 gene (Cdh23

Indexed as

Polymorphism, Single NucleotideQuantitative Trait LociAllelesAmino Acid SubstitutionAnimalsAuditory ThresholdCadherinsCochleaEvoked Potentials, Auditory, Brain StemFemaleGene ExpressionHumansMiceMice, Inbred C57BLMice, Inbred StrainsMutationCadherinsCdh23 protein, mouse

Identifiers

PMID28287619
PMCPMC5347380
OpenAlexW2596343924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.