ArticleScientific reports2017
Metabolomics of the tick-Borrelia interaction during the nymphal tick blood meal.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line.Medical and veterinary entomology · 2026Article
- A Deep Learning Approach for Classifying Developmental Stages ofSensors (Basel, Switzerland) · 2025Article
- Ticks' tricks: immunomodulatory effects of ixodid tick saliva at the cutaneous tick-host interface.Frontiers in immunology · 2025Review
- Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection.Nature microbiology · 2024Article
- Functional analysis of Rickettsia monacensis strain humboldt folA dihydrofolate reductase gene via complementation assay.Ticks and tick-borne diseases · 2023Article
- The arginine deaminase system plays distinct roles in Borrelia burgdorferi and Borrelia hermsii.PLoS pathogens · 2022Article
- Hematophagy and tick-borne Rickettsial pathogen shape the microbial community structure and predicted functions within the tick vector,Frontiers in cellular and infection microbiology · 2022Article
- Quantitative Parameters of the Body Composition Influencing Host Seeking Behavior ofPathogens (Basel, Switzerland) · 2021Article
- Interactions between Borrelia burgdorferi and its hosts across the enzootic cycle.Parasite immunology · 2021Review
- Insights into the molecular basis of tick-borne encephalitis from multiplatform metabolomics.PLoS neglected tropical diseases · 2021Article
- Alpha-Gal Syndrome: Involvement ofFrontiers in cellular and infection microbiology · 2021Article
- Interactions Between Ticks and Lyme Disease Spirochetes.Current issues in molecular biology · 2021Article
- Review
- Immunometabolism in Arthropod Vectors: Redefining Interspecies Relationships.Trends in parasitology · 2020Review
- Sharing the Ride:Frontiers in cellular and infection microbiology · 2020Review
- Controlling Lyme Disease: New Paradigms for Targeting the Tick-Pathogen-Reservoir Axis on the Horizon.Frontiers in cellular and infection microbiology · 2020Article
- The alpha-Gal syndrome: new insights into the tick-host conflict and cooperation.Parasites & vectors · 2019Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The causal agents of Lyme disease in North America, Borrelia burgdorferi and Borrelia mayonii, are transmitted primarily by Ixodes scapularis ticks. Due to their limited metabolic capacity, spirochetes rely on the tick blood meal for nutrients and metabolic intermediates while residing in the tick vector, competing with the tick for nutrients in the blood meal. Metabolomics is an effective methodology to explore dynamics of spirochete survival and multiplication in tick vectors before transmission to a vertebrate host via tick saliva. Using gas chromatography coupled to mass spectrometry, we identified statistically significant differences in the metabolic profile among uninfected I. scapularis nymphal ticks, B. burgdorferi-infected nymphal ticks and B. mayonii-infected nymphal ticks by measuring metabolism every 24 hours over the course of their up to 96 hour blood meals. Specifically, differences in the abundance of purines, amino acids, carbohydrates, and fatty acids during the blood meal among the three groups of nymphal ticks suggest that B. mayonii and B. burgdorferi may have different metabolic capabilities, especially during later stages of nymphal feeding. Understanding mechanisms underlying variable metabolic requirements of different Lyme disease spirochetes within tick vectors could potentially aid development of novel methods to control spirochete transmission.
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