Evidence map›Paper›PMID 28287486›Full record

Trial reportNutrients2017

CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study.

Juan J Salinero, Beatriz Lara, Diana Ruiz-Vicente, Francisco Areces, Carlos Puente-Torres, César Gallo-Salazar, Teodoro Pascual, Juan Del Coso

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Juan J SalineroExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, Spain. jjsalinero@ucjc.edu.
Beatriz LaraExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, Spain. blara@ucjc.edu.
Diana Ruiz-VicenteExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, Spain. diruiz@ucjc.edu.
Francisco ArecesExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, Spain. fareces@ucjc.edu.
Carlos Puente-TorresExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, Spain. carlos.puente@sek.es.
César Gallo-SalazarExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, Spain. cgallo@ucjc.edu.
Teodoro PascualExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, Spain. tpascual@ucjc.edu.
Juan Del CosoExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, Spain. jdelcoso@ucjc.edu.
Camilo José Cela University · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous investigations have determined that some individuals have minimal or even ergolytic performance effects after caffeine ingestion. The aim of this study was to analyze the influence of the genetic variations of the CYP1A2 gene on the performance enhancement effects of ingesting a moderate dose of caffeine. In a double-blind randomized experimental design, 21 healthy active participants (29.3 ± 7.7 years) ingested 3 mg of caffeine per kg of body mass or a placebo in testing sessions separated by one week. Performance in the 30 s Wingate test, visual attention, and side effects were evaluated. DNA was obtained from whole blood samples and the CYP1A2 polymorphism was analyzed (rs762551). We obtained two groups: AA homozygotes (

Indexed as

Exercise5' Flanking RegionAdultAllelesAnxietyAttentionCaffeineCytochrome P-450 CYP1A2Dietary SupplementsDouble-Blind MethodFemaleGenetic Association StudiesHeterozygoteHomozygoteHumansMaleCaffeineCYP1A2 protein, humanCytochrome P-450 CYP1A2Performance-Enhancing Substancescyclingergogenic aidgeneticsperformanceside effects

Identifiers

PMID28287486
PMCPMC5372932
OpenAlexW2595836811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.