Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions.

Patrycja Miszczyk, Ilona Turowska-Tyrk, Paweł Kafarski, Ewa Chmielewska

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media.RSC advances · 2020
Review
Three-Component Reaction of Diamines with Triethyl Orthoformate and Diethyl Phosphite and Anti-Proliferative and Antiosteoporotic Activities of the Products.Molecules (Basel, Switzerland) · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Patrycja MiszczykDepartment of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, 50-370 Wrocław, Poland. patrycja.miszczyk@pwr.edu.pl.

Ilona Turowska-TyrkThe Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland. ilona.turowska-tyrk@pwr.edu.pl.

Paweł KafarskiDepartment of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, 50-370 Wrocław, Poland. pawel.kafarski@pwr.edu.pl.

Ewa ChmielewskaDepartment of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, 50-370 Wrocław, Poland. ewa.chmielewska@pwr.edu.pl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reaction between benzyl amines, triethyl orthoformate, and diethyl phosphite affords either bisphosphonic (compound

Indexed as

BenzylaminesCatalysisChemistry Techniques, SyntheticCrystallography, X-RayDiphosphonatesFormatesModels, MolecularOrganophosphonatesPhosphitesalpha-benzylaminobenzylphosphonic acidBenzylaminesDiphosphonatesFormatesOrganophosphonatesPhosphitesaminophosphonatesbisphosphonatesmulticomponent reactionsN-benzylaminobenzylphosphonatesN-benzylaminomethylenebisphosphonic acidsynthesis of C-P bond

Identifiers

PMID28287472

DOI10.3390/molecules22030450

PMCPMC6155184

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.