ArticleMolecules (Basel, Switzerland)2017
Alkoxy and Enediyne Derivatives Containing 1,4-Benzoquinone Subunits-Synthesis and Antitumor Activity.
Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 22 citations in OpenAlex.
- Exploring the Therapeutic Marvels: A Comprehensive Review on the Biological Potential of Quinoline-5,8-Dione.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024Review
- Hybrids of 1,4-Naphthoquinone with Thymidine Derivatives: Synthesis, Anticancer Activity, and Molecular Docking Study.Molecules (Basel, Switzerland) · 2023Article
- Article
- Synthesis and biological evaluation of coumarin-quinone hybrids as multifunctional bioactive agents.ADMET & DMPK · 2023Article
- Hybrids of 1,4-Quinone with Quinoline Derivatives: Synthesis, Biological Activity, and Molecular Docking with DT-Diaphorase (NQO1).Molecules (Basel, Switzerland) · 2022Article
- NQO1 protects against clioquinol toxicity.Frontiers in pharmacology · 2022Article
- Lipophilicity, Pharmacokinetic Properties, and Molecular Docking Study on SARS-CoV-2 Target for Betulin Triazole Derivatives with Attached 1,4-Quinone.Pharmaceutics · 2021Article
- Synthesis of some NH- and NH,S- substituted 1,4-quinones.Turkish journal of chemistry · 2021Article
- 5,8-Quinolinedione Scaffold as a Promising Moiety of Bioactive Agents.Molecules (Basel, Switzerland) · 2019Review
- Characterization and Trypanocidal Activity of a Novel Pyranaphthoquinone.Molecules (Basel, Switzerland) · 2017Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The compounds produced by a living organism are most commonly as medicinal agents and starting materials for the preparation of new semi-synthetic derivatives. One of the largest groups of natural compounds consists of products containing a 1,4-benzoquinone subunit. This fragment occurs in three enediyne antibiotics, dynemicin A, deoxydynemicin A, and uncilamicin, which exhibit high biological activity. A series of alkoxy derivatives containing 1,4-naphthoquinone, 5,8-quinolinedione, and 2-methyl-5,8-quinolinedione moieties was synthesized. Moreover, the 1,4-benzoquinone subunit was contacted with an enediyne fragment. All obtained compounds were characterized by spectroscopy and spectrometry methods. The resulting alkane, alkene, alkyne and enediyne derivatives were tested as antitumor agents. They showed high cytotoxic activity depending on the type of 1,4-benzoquinone subunit and the employed tumor cell lines. The synthesized derivatives fulfill the Lipinski Rule of Five and have low permeability through the blood-brain barrier.
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