Evidence map›Paper›PMID 28287337›Full record

ArticlemAbs

Generation and characterization of protective antibodies to Marburg virus.

Jeffrey W Froude, Thibaut Pelat, Sebastian Miethe, Samantha E Zak, Anna Z Wec, Kartik Chandran, Jennifer Mary Brannan, Russell R Bakken, Michael Hust, Philippe Thullier and 1 more

Abstract read
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Antibody Selection in Solution Using Magnetic Beads.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM) · 2021
    Review
  10. Review
  11. An update on antiviral antibody-based biopharmaceuticals.International immunopharmacology · 2020
    Review
  12. Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM) · 2020
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jeffrey W Froudea US Army Medical Research Institute for Infectious Disease (USAMRIID) , Fort Detrick , MD , USA.
Thibaut Pelatb Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees [IRBA-CRSSA] , La Tronche , France.
Sebastian Miethed Technische Universität Braunschweig, Institut für Biochemie, Biotechnologie und Bioinformatik Braunschweig , Germany.
Samantha E Zaka US Army Medical Research Institute for Infectious Disease (USAMRIID) , Fort Detrick , MD , USA.
Anna Z Wecf Department of Microbiology and Immunology , Albert Einstein College of Medicine , Bronx , NY , USA.
Kartik Chandranf Department of Microbiology and Immunology , Albert Einstein College of Medicine , Bronx , NY , USA.
Jennifer Mary Brannana US Army Medical Research Institute for Infectious Disease (USAMRIID) , Fort Detrick , MD , USA.
Russell R Bakkena US Army Medical Research Institute for Infectious Disease (USAMRIID) , Fort Detrick , MD , USA.
Michael Hustd Technische Universität Braunschweig, Institut für Biochemie, Biotechnologie und Bioinformatik Braunschweig , Germany.
Philippe Thullierb Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees [IRBA-CRSSA] , La Tronche , France.
John M Dyea US Army Medical Research Institute for Infectious Disease (USAMRIID) , Fort Detrick , MD , USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marburg virus (MARV) and Ebola virus (EBOV) have been a source of epidemics and outbreaks for several decades. We present here the generation and characterization of the first protective antibodies specific for wild-type MARV. Non-human primates (NHP), cynomolgus macaques, were immunized with viral-replicon particles expressing the glycoproteins (GP) of MARV (Ci67 isolate). An antibody fragment (single-chain variable fragment, scFv) phage display library was built after four immunogen injections, and screened against the GP

Indexed as

Antibody SpecificityAnimalsAntibodies, ViralHumansMacaca fascicularisMarburgvirusSingle-Chain AntibodiesAntibodies, ViralSingle-Chain AntibodiesAntibodybiodefenseebolafilovirushemorrhagicMarburgmurineprotectiontherapeutic

Identifiers

PMID28287337
PMCPMC5419075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.