Evidence map›Paper›PMID 28287239›Full record

ArticleChemical communications (Cambridge, England)2017

Structural insights into the EthR-DNA interaction using native mass spectrometry.

Daniel Shiu-Hin Chan, Wei-Guang Seetoh, Brendan N McConnell, Dijana Matak-Vinković, Sherine E Thomas, Vitor Mendes, Michal Blaszczyk, Anthony G Coyne, Tom L Blundell, Chris Abell

Open access · hybridAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Daniel Shiu-Hin ChanDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.
Wei-Guang SeetohDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.ORCID http://orcid.org/0000-0002-1138-6581
Brendan N McConnellDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.ORCID http://orcid.org/0000-0001-9002-9808
Dijana Matak-VinkovićDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.
Sherine E ThomasDepartment of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
Vitor MendesDepartment of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.ORCID http://orcid.org/0000-0002-2734-2444
Michal BlaszczykDepartment of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
Anthony G CoyneDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.
Tom L BlundellDepartment of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
Chris AbellDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.ORCID http://orcid.org/0000-0001-9174-1987
University of Cambridge · GB

Funding

Wellcome Trust 090340
6 · The paper itself

Abstract

EthR is a transcriptional repressor that increases Mycobacterium tuberculosis resistance to ethionamide. In this study, the EthR-DNA interaction has been investigated by native electrospray-ionization mass spectrometry for the first time. The results show that up to six subunits of EthR are able to bind to its operator.

Indexed as

CalorimetryDNA, BacterialDrug Resistance, BacterialEthionamideMycobacterium tuberculosisSpectrometry, Mass, Electrospray IonizationThermodynamicsDNA, BacterialEthionamide

Identifiers

PMID28287239
PMCPMC5868724
OpenAlexW2593014637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.