ArticleScientific reports2017
Enhanced osteogenesis and angiogenesis by mesoporous hydroxyapatite microspheres-derived simvastatin sustained release system for superior bone regeneration.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- High-throughput synthesis of zinc-functionalized bio-ceramics propels the rational design of bone implants.Bioactive materials · 2026Article
- Histomorphometric Evaluation of Socket Preservation Healing Using Xenogeneic Bone Substitute Combined with Statin: A Prospective Split-Mouth Clinical Pilot Study.Acta stomatologica Croatica · 2026Article
- The Mechanism of Simvastatin-Mediated M1 Macrophage Polarization Contributing to Osteogenesis and Angiogenesis.Biomedicines · 2025Article
- Physical and drug- releasing properties of a cement containing simvastatin (SimCeram).BMC oral health · 2025Article
- Silver Nanoparticles and Simvastatin-Loaded PLGA-Coated Hydroxyapatite/Calcium Carbonate Scaffolds.Nanomaterials (Basel, Switzerland) · 2024Article
- Simvastatin Induces Apoptosis but Attenuates Migration in SCAPs.International dental journal · 2024Article
- Simvastatin-loaded 3D aerogel scaffolds promote bone regeneration.Bio-medical materials and engineering · 2024Article
- Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach.Journal of nanobiotechnology · 2023Review
- Nano-Hydroxyapatite Composite Scaffolds Loaded with Bioactive Factors and Drugs for Bone Tissue Engineering.International journal of molecular sciences · 2023Review
- Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways.Stem cell research & therapy · 2022Review
- Effect of Angiogenesis in Bone Tissue Engineering.Annals of biomedical engineering · 2022Review
- Potential bioactive coating system for high-performance absorbable magnesium bone implants.Bioactive materials · 2022Review
- Simvastatin-Loaded Nanofibrous Membrane Efficiency on the Repair of Achilles Tendons.International journal of nanomedicine · 2022Article
- Dentin Matrix Protein 1 Silencing Inhibits Phosphorus Utilization in Primary Cultured Tibial Osteoblasts of Broiler Chicks.Frontiers in veterinary science · 2022Article
- Long non-coding RNA MALAT1 enhances angiogenesis during bone regeneration by regulating the miR-494/SP1 axis.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Effects of statins on the biological features of mesenchymal stem cells and therapeutic implications.Heart failure reviews · 2021Review
- [Effect of demineralized bone matrix modified by laminin α4 chain functional peptide on H-type angiogenesis and osteogenesis to promote bone defect repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Article
- Combined Delivery of Two Different Bioactive Factors Incorporated in Hydroxyapatite Microcarrier for Bone Regeneration.Tissue engineering and regenerative medicine · 2020Article
- [Application status of hypoxia mimetic agents in bone tissue engineering].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Article
- Modified electrospun chitosan membranes for controlled release of simvastatin.International journal of pharmaceutics · 2020Article
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12 authors.
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Abstract
Biomaterials with both excellent osteogenic and angiogenic activities are desirable to repair massive bone defects. In this study, simvastatin with both osteogenic and angiogenic activities was incorporated into the mesoporous hydroxyapatite microspheres (MHMs) synthesized through a microwave-assisted hydrothermal method using fructose 1,6-bisphosphate trisodium salt (FBP) as an organic phosphorous source. The effects of the simvastatin-loaded MHMs (S-MHMs) on the osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) and angiogenesis in EA.hy926 cells were investigated. The results showed that the S-MHMs not only enhanced the expression of osteogenic markers in rBMSCs but also promoted the migration and tube formation of EA.hy926 cells. Furthermore, the S-MHMs were incorporated into collagen matrix to construct a novel S-MHMs/collagen composite scaffold. With the aid of MHMs, the water-insoluble simvastatin was homogenously incorporated into the hydrophilic collagen matrix and presented a sustained release profile. In vivo experiments showed that the S-MHMs/collagen scaffolds enhanced the bone regeneration and neovascularization simultaneously. These results demonstrated that the water-insoluble simvastatin could be incorporated into the MHMs and maintained its biological activities, more importantly, the S-MHMs/collagen scaffolds fabricated in this study are of immense potential in bone defect repair by enhancing osteogenesis and angiogenesis simultaneously.
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