ArticleScientific reports2017
Killing of Staphylococcus aureus and Salmonella enteritidis and neutralization of lipopolysaccharide by 17-residue bovine lactoferricins: improved activity of Trp/Ala-containing molecules.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Lactoferrin bridges antimicrobial and healing responses inFrontiers in microbiology · 2025Review
- Vanillin Has Potent Antibacterial, Antioxidant, and Anti-Inflammatory Activities In Vitro and in Mouse Colitis Induced by Multidrug-ResistantAntioxidants (Basel, Switzerland) · 2024Article
- A cleavable chimeric peptide with targeting and killing domains enhances LPS neutralization and antibacterial properties against multi-drug resistant E. coli.Communications biology · 2023Article
- Lactoferrin, a Great Wall of host-defence?Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Effect of NZ2114 againstFrontiers in microbiology · 2022Article
- Editorial: Antimicrobial Peptides: Molecular Design, Structure-Function Relationship, and Biosynthesis Optimization.Frontiers in microbiology · 2022Article
- Diverse Mechanisms of Antimicrobial Activities of Lactoferrins, Lactoferricins, and Other Lactoferrin-Derived Peptides.International journal of molecular sciences · 2021Review
- Secondary Structural Transformation of Bovine Lactoferricin Affects Its Antibacterial Activity.Probiotics and antimicrobial proteins · 2021Article
- Design and Pharmacodynamics of Recombinant Fungus Defensin NZL with Improved Activity againstInternational journal of molecular sciences · 2021Article
- The Pharmacodynamics Study of Insect Defensin DLP4 Against ToxigenicFrontiers in cellular and infection microbiology · 2021Article
- Dual Antibacterial Activities and Biofilm Eradication of a Marine Peptide-N6NHInternational journal of molecular sciences · 2020Article
- Article
- Recombinant of the Staphylococcal Bacteriophage Lysin CHAPMicroorganisms · 2020Article
- Article
- Mode of action of plectasin-derived peptides against gas gangrene-associated Clostridium perfringens type A.PloS one · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine lactoferricin (LfcinB) has potent antibacterial, antifungal and antiparasitic activities but is also hemolytic. Our objective was to identify LfcinB17-31 derivatives with reduced hemolysis and improved antimicrobial activity via substituting Cys3, Arg4, Gln7, Met10, and Gly14 with more hydrophobic residues. Two peptides, Lfcin4 and Lfcin5, showed higher activity against Staphylococcus aureus and Salmonella enteritidis and lower hemolytic activity than the parent peptide LfcinB17-31. These peptides permeabilized the outer and inner membranes of S. enteritidis; however, Lfcin5 did not permeabilize the inner membrane of S. aureus. Gel retardation and circular dichroism spectra showed that Lfcin4 and Lfcin5 bound to bacterial genomic DNA. Lfcin4 inhibited DNA, RNA and protein synthesis. Both peptides induced the peeling of membranes and the lysis of S. enteritidis. At doses of 10 and 15 mg/kg, Lfcin4 and Lfcin5 reduced the bacterial counts in infected thigh muscles by 0.03‒0.10 and 0.05‒0.63 log
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Registered trials
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