Evidence map›Paper›PMID 28287147›Full record

Trial reportScientific reports2017

Radiation-associated circulatory disease mortality in a pooled analysis of 77,275 patients from the Massachusetts and Canadian tuberculosis fluoroscopy cohorts.

Van Tran, Lydia B Zablotska, Alina V Brenner, Mark P Little

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Review
  6. Radiotherapy for non-cancer diseases: benefits and long-term risks.International journal of radiation biology · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. In Reply to Welsh et al.International journal of radiation oncology, biology, physics · 2021
    Article
  12. Review
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  14. Low-dose radiotherapy for COVID-19 pneumonia treatment: case report, procedure, and literature review.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020
    Review
  15. Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020
    Review
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Van TranRadiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-9778, USA.
Lydia B ZablotskaDepartment of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Alina V BrennerRadiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-9778, USA.
Mark P LittleRadiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-9778, USA.
National Cancer Institute · USUniversity of California, San Francisco · US

Funding

Canadian Fluoroscopy Cohort Study: Lifespan Mortality and Incidence Follow-UpR01CA197422 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZABLOTSKA, LYDIA B · 2016 to 2020
$3.4M
Risk of hematologic cancers from repeated low-dose diagnostic radiationR03CA188614 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZABLOTSKA, LYDIA B · 2014 to 2015
$158k
NCI NIH HHS R01 CA197422NCI NIH HHS R03 CA188614
6 · The paper itself

Abstract

High-dose ionising radiation is associated with circulatory disease. Risks associated with lower-dose (<0.5 Gy) exposures remain unclear, with little information on risk modification by age at exposure, years since exposure or dose-rate. Tuberculosis patients in Canada and Massachusetts received multiple diagnostic x-ray fluoroscopic exposures, over a wide range of ages, many at doses <0.5 Gy. We evaluated risks of circulatory-disease mortality associated with <0.5 Gy radiation exposure in a pooled cohort of 63,707 patients in Canada and 13,568 patients in Massachusetts. Under 0.5 Gy there are increasing trends for all circulatory disease (n = 10,209; excess relative risk/Gy = 0.246; 95% CI 0.036, 0.469; p = 0.021) and for ischaemic heart disease (n = 6410; excess relative risk/Gy = 0.267; 95% CI 0.003, 0.552; p = 0.048). All circulatory-disease and ischaemic-heart-disease risk reduces with increasing time since exposure (p < 0.005). Over the entire dose range, there are negative mortality dose trends for all circulatory disease (p = 0.014) and ischaemic heart disease (p = 0.003), possibly due to competing causes of death over this dose interval.These results confirm and extend earlier findings and strengthen the evidence for circulatory-disease mortality radiation risk at doses <0.5 Gy. The limited information on well-known lifestyle/medical risk factors for circulatory disease implies that confounding of the dose trend cannot be entirely excluded.

Indexed as

AdolescentAdultCanadaChildChild, PreschoolFluoroscopyHumansInfantInfant, NewbornMaleMiddle AgedMyocardial IschemiaRadiation InjuriesRisk FactorsTuberculosis

Identifiers

PMID28287147
PMCPMC5347030
OpenAlexW2595850032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.