Evidence map›Paper›PMID 28287095›Full record

ArticleScientific reports2017

Aboriginal Australian mitochondrial genome variation - an increased understanding of population antiquity and diversity.

Nano Nagle, Mannis van Oven, Stephen Wilcox, Sheila van Holst Pellekaan, Chris Tyler-Smith, Yali Xue, Kaye N Ballantyne, Leah Wilcox, Luka Papac, Karen Cooke and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  7. The genetic origins and impacts of historical Papuan migrations into Wallacea.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  19. When didProceedings of the National Academy of Sciences of the United States of America · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nano NagleDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, Victoria, Australia.
Mannis van OvenDepartment of Genetic Identification, Erasmus MC University Medical Center Rotterdam, The Netherlands.
Stephen WilcoxAustralian Genome Research Facility, Melbourne, Victoria, Australia.
Sheila van Holst PellekaanBiotechnology and Biomolecular Sciences, University of New South Wales, New South Wales, Australia.
Chris Tyler-SmithThe Wellcome Trust Sanger Institute, Welcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Yali XueThe Wellcome Trust Sanger Institute, Welcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Kaye N BallantyneDepartment of Genetic Identification, Erasmus MC University Medical Center Rotterdam, The Netherlands.
Leah WilcoxDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, Victoria, Australia.
Luka PapacDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, Victoria, Australia.
Karen CookeDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, Victoria, Australia.
Roland A H van OorschotOffice of the Chief Forensic Scientist, Victoria Police Forensic Services Department, Melbourne, Victoria, Australia.
Peter McAllisterGriffith University, Queensland, Australia.
Lesley WilliamsCommunity Elder and Cultural Advisor, Brisbane, Queensland, Australia.
Manfred KayserDepartment of Genetic Identification, Erasmus MC University Medical Center Rotterdam, The Netherlands.
R John MitchellDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, Victoria, Australia.
Genographic Consortium

Funding

Wellcome Trust 098051
6 · The paper itself

Abstract

Aboriginal Australians represent one of the oldest continuous cultures outside Africa, with evidence indicating that their ancestors arrived in the ancient landmass of Sahul (present-day New Guinea and Australia) ~55 thousand years ago. Genetic studies, though limited, have demonstrated both the uniqueness and antiquity of Aboriginal Australian genomes. We have further resolved known Aboriginal Australian mitochondrial haplogroups and discovered novel indigenous lineages by sequencing the mitogenomes of 127 contemporary Aboriginal Australians. In particular, the more common haplogroups observed in our dataset included M42a, M42c, S, P5 and P12, followed by rarer haplogroups M15, M16, N13, O, P3, P6 and P8. We propose some major phylogenetic rearrangements, such as in haplogroup P where we delinked P4a and P4b and redefined them as P4 (New Guinean) and P11 (Australian), respectively. Haplogroup P2b was identified as a novel clade potentially restricted to Torres Strait Islanders. Nearly all Aboriginal Australian mitochondrial haplogroups detected appear to be ancient, with no evidence of later introgression during the Holocene. Our findings greatly increase knowledge about the geographic distribution and phylogenetic structure of mitochondrial lineages that have survived in contemporary descendants of Australia's first settlers.

Indexed as

Genetic VariationGenome, MitochondrialPhylogenyAustraliaHumansSequence Analysis, DNA

Identifiers

PMID28287095
PMCPMC5347126

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