ReviewActa orthopaedica2017
Poor relation between biomechanical and clinical studies for the proximal femoral locking compression plate.
Review in Acta orthopaedica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05286905 (Biomechanical Testing, Finite Element Analysis and Pilot, Prospective, Randomized, Experimental Clinical Study of Osteosynthesis of Reverse Oblique Peritrochanteric Fractures With PFLP vs Cephalomedullary Nail.), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biomechanical Testing, Finite Element Analysis and Pilot, Prospective, Randomized, Experimental Clinical Study of Osteosynthesis of Reverse Oblique Peritrochanteric Fractures With PFLP vs Cephalomedullary Nail.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- The correlation between biomechanical experiments and clinical studies in orthopedics: a systematic review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Pooled it
- Biomechanically superior treatments do not translate into improved outcomes in randomized controlled trials.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022Pooled it
- Similar outcome of femoral neck fractures treated with Pinloc or Hansson Pins: 1-year data from a multicenter randomized clinical study on 439 patients.Acta orthopaedica · 2019Trial
- Four different fixation strategies for ipsilateral femoral neck and shaft fractures: a finite element analysis.Journal of orthopaedic surgery and research · 2026Article
- Functional morphology of trabecular system in human proximal femur: a perspective from P45 sectional plastination and 3D reconstruction finite element analysis.Journal of orthopaedic surgery and research · 2025Article
- Mortality following proximal femoral fractures in elderly patients: a large retrospective cohort study of incidence and risk factors.BMC musculoskeletal disorders · 2023Article
- Early Failure of Locking Compression Plates in Pediatric Proximal Femoral Fracture.Journal of the Pediatric Orthopaedic Society of North America · 2023Article
- Strategies for fixation of periprosthetic fragility fractures of the neck of femur below a well-functioning hip resurfacing arthroplasty: A case-series.Journal of clinical orthopaedics and trauma · 2023Article
- Proximal femoral bionic nail-a novel internal fixation system for the treatment of femoral neck fractures: a finite element analysis.Frontiers in bioengineering and biotechnology · 2023Article
- [Research progress in biomechanics of common internal fixation for femoral neck fracture].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022Article
- Intramedullary nailing in opening wedge high tibial osteotomy-in vitro test for validation of a method of fixation.International orthopaedics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose - The proximal femur locking compression plate (PF-LCP) is a new concept in the treatment of hip fractures. When releasing new implants onto the market, biomechanical studies are conducted to evaluate performance of the implant. We investigated the relation between biomechanical and clinical studies on PF-LCP. Methods - A systematic literature search of relevant biomechanical and clinical studies was conducted in PubMed on December 1, 2015. 7 biomechanical studies and 15 clinical studies were included. Results - Even though the biomechanical studies showed equivalent or higher failure loads for femoral neck fracture, the clinical results were far worse, with a 37% complication rate. There were no biomechanical studies on pertrochanteric fractures. Biomechanical studies on subtrochanteric fractures showed that PF-LCP had a lower failure load than with proximal femoral nail, but higher than with angled blade plate. 4 clinical studies had complication rates less than 8% and 9 studies had complication rates between 15% and 53%. Interpretation - There was no clear relation between biomechanical and clinical studies. Biomechanical studies are generally inherently different from clinical studies, as they examine the best possible theoretical use of the implant without considering the long-term outcome in a clinical setting. Properly designed clinical studies are mandatory when introducing new implants, and they cannot be replaced by biomechanical studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.