ArticleJournal of virology1988
Both VP2 and VP3 are synthesized from each of the alternative spliced late 19S RNA species of simian virus 40.
Article in Journal of virology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Minimal Genome, Maximal Effect: How Polyomavirus Genomes Are Capable of Complex Pathogenesis.Viruses · 2026Review
- Evidence of the Mechanism by Which Polyomaviruses Exploit the Extracellular Vesicle Delivery System during Infection.Viruses · 2020Review
- Does the Evidence Support the Existence of the Simian Polyomavirus SV40 Vp4 Viroporin?mSphere · 2020Article
- Association Between Simian Virus 40 and Human Tumors.Frontiers in oncology · 2019Review
- The miRNA world of polyomaviruses.Virology journal · 2013Review
- The viroporin activity of the minor structural proteins VP2 and VP3 is required for SV40 propagation.The Journal of biological chemistry · 2013Article
- The Merkel cell polyomavirus minor capsid protein.PLoS pathogens · 2013Article
- 19S late mRNAs of simian virus 40 have an internal ribosome entry site upstream of the virion structural protein 3 coding sequence.Journal of virology · 2006Article
- Analysis of capsid formation of human polyomavirus JC (Tokyo-1 strain) by a eukaryotic expression system: splicing of late RNAs, translation and nuclear transport of major capsid protein VP1, and capsid assembly.Journal of virology · 2000Article
- Modifications of the 5' cap of mRNAs during Xenopus oocyte maturation: independence from changes in poly(A) length and impact on translation.Molecular and cellular biology · 1998Article
- Oligomerization and maturation of Na,K-ATPase: functional interaction of the cytoplasmic NH2 terminus of the beta subunit with the alpha subunit.The Journal of cell biology · 1996Article
- Modulation of the Na,K-pump function by beta subunit isoforms.The Journal of general physiology · 1994Article
- Role of the transmembrane and extracytoplasmic domain of beta subunits in subunit assembly, intracellular transport, and functional expression of Na,K-pumps.The Journal of cell biology · 1993Article
- Three new members of the RNP protein family in Xenopus.Nucleic acids research · 1993Article
- Functional binding of the "TATA" box binding component of transcription factor TFIID to the -30 region of TATA-less promoters.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Recognition of SV40-VP2 in the infected cell by antipeptide antibodies.Archives of virology · 1992Article
- Coexpression of alpha 1 with putative beta 3 subunits results in functional Na+/K+ pumps in Xenopus oocytes.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Leader-encoded open reading frames modulate both the absolute and relative rates of synthesis of the virion proteins of simian virus 40.Journal of virology · 1989Article
- Oligonucleotide-targeted degradation of U1 and U2 snRNAs reveals differential interactions of simian virus 40 pre-mRNAs with snRNPs.Nucleic acids research · 1989Article
- The scanning model for translation: an update.The Journal of cell biology · 1989Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The late 19S RNAs of simian virus 40 consist of a family of alternatively spliced RNAs, each of which contains open reading frames corresponding to all three of the virion proteins. Two approaches were used to test the hypothesis that each alternatively spliced 19S RNA species is translated to synthesize preferentially only one of the virion proteins. First, we analyzed the synthesis of virion proteins in simian virus 40 mutant-infected monkey cells that accumulate predominantly either only one spliced 19S RNA species or only the 19S RNAs. Second, we determined the virion proteins synthesized in a rabbit reticulocyte lysate programmed with specific, in vitro-transcribed 19S RNA species. These results indicated that VP2 and VP3, but not VP1, are synthesized from all 19S RNA species. Quantitative analysis of these data indicated that individual 19S RNA species containing a translation initiation signal upstream of the VP2 AUG codon were translated in a cell extract three- to fivefold less efficiently than were 19S RNA species lacking this signal and that the precise rate of synthesis of VP2 relative to VP3 varied somewhat with the sequence of the leader region. These data are consistent with the synthesis of VP2 and VP3 occurring by a leaky scanning mechanism in which initiation of translation at a specific AUG codon is affected by both (i) the intrinsic efficiency of ribosomes recognizing the sequences surrounding the AUG codon as an initiation signal and (ii) partial interference from 5'-proximal initiation signals and their corresponding open reading frames.
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