ArticleLaryngoscope investigative otolaryngology2017
D-amino acids do not inhibit
Article in Laryngoscope investigative otolaryngology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Influence of Amino Acids on Quorum Sensing-Related Pathways inMetabolites · 2025Article
- Quantification of Pseudomonas aeruginosa biofilms using electrochemical methods.Access microbiology · 2025Article
- d-Methionine-induced DNases disperse establishedBiofilm · 2024Article
- Metabolomic Approaches to Study the Potential Inhibitory Effects of Plantaricin Q7 againstFoods (Basel, Switzerland) · 2024Article
- D-histidine combated biofilm formation and enhanced the effect of amikacin against Pseudomonas aeruginosa in vitro.Archives of microbiology · 2024Article
- Promising applications of D-amino acids in periprosthetic joint infection.Bone research · 2023Review
- Tryptophan, an important link in regulating the complex network of skin immunology response in atopic dermatitis.Frontiers in immunology · 2023Review
- Temporal Hierarchy and Context-Dependence of Quorum Sensing Signal inLife (Basel, Switzerland) · 2022Article
- Combination Therapies for Biofilm Inhibition and Eradication: A Comparative Review of Laboratory and Preclinical Studies.Frontiers in cellular and infection microbiology · 2022Review
- d-Amino Acids and Lactic Acid Bacteria.Microorganisms · 2019Review
- D-fining DarR: a LysR-type transcriptional regulator that responds to D-aspartate.Journal of bacteriology · 2018Article
- New Insights Into the Mechanisms and Biological Roles of D-Amino Acids in Complex Eco-Systems.Frontiers in microbiology · 2018Review
- Application of D-Amino Acids as Biofilm Dispersing Agent in Dental Unit Waterlines.International journal of dentistry · 2018Article
- Mitigation of a nitrate reducing Pseudomonas aeruginosa biofilm and anaerobic biocorrosion using ciprofloxacin enhanced by D-tyrosine.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveSTUDY
designWe evaluated the effect of D-alanine (10 mM), D-leucine (10 mM), D-methionine (10 mM), D-tryptophan (10 mM), and D-tyrosine (10 uM and 1 mM) on biofilm formation in two commonly studied laboratory strains of
methodsBiofilms were grown in 24-well and 96-well tissue culture plates, documented photographically and stained with 0.1% crystal violet and solubilized in 33% glacial acetic acid for quantification.
resultsIn strains PAO1 and PA14, the addition of D-amino acids did not result in an inhibitory effect on biofilm growth in 24-well plates. Repeating the study in 96-well plates confirmed our findings that D-amino acids do not inhibit biofilm formation of
conclusionWe conclude that D-amino acids only slow the production of biofilms rather than completely prevent biofilm formation; therefore, D-amino acids represent a poor option for potential clinically therapeutic interventions. LEVEL OF EVIDENCE: N/A.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.