ReviewTherapeutic advances in gastroenterology2017
Antispasmodic drugs in colonoscopy: a review of their pharmacology, safety and efficacy in improving polyp detection and related outcomes.
Review in Therapeutic advances in gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Submucosal Lidocaine Injection in Colonic Endoscopic Submucosal Dissection: A Single-Center, Double-Blind, Randomized Controlled Trial.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Trial
- Perianal lidocaine application during unsedated colonoscopy: A double-blind randomized controlled trial.PloS one · 2026Trial
- The efficacy of the submucosal injection of lidocaine during endoscopic submucosal dissection for colorectal neoplasms: a multicenter randomized controlled study.Surgical endoscopy · 2021Trial
- Oral IBGard™ Before Colonoscopy: A Single-Center Double-Blinded, Randomized, Placebo-Controlled Trial.Digestive diseases and sciences · 2021Trial
- Trial
- Article
- Antispasmodic Activity of Green-Synthesized Phenylaminojuglones: In Vitro and In Silico Studies.ACS omega · 2026Article
- Efficacy and Safety of L-Menthol During Gastrointestinal Endoscopy-A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Journal of clinical medicine · 2025Review
- Risk factors for motion artifacts in fast spin-echo T2-weighted imaging of the prostate magnetic resonance imaging: a retrospective study.Radiological physics and technology · 2025Article
- MRI for endometriosis in adolescent patients.Pediatric radiology · 2025Review
- Mitigating digestive disorders: Action mechanisms of Mediterranean herbal active compounds.Open life sciences · 2024Review
- Difficult colorectal polypectomy: Technical tips and recent advances.World journal of gastroenterology · 2023Review
- Association Between the Cool Temperature-dependent Suppression of Colonic Peristalsis and Transient Receptor Potential Melastatin 8 Activation in Both a Randomized Clinical Trial and an Animal Model.Journal of neurogastroenterology and motility · 2022Article
- Utility of PET Scans in the Diagnosis and Management of Gastrointestinal Tumors.Digestive diseases and sciences · 2022Article
- Image-enhanced endoscopy and endoscopic resection practices in the colon among endoscopists in India.Endoscopy international open · 2022Article
- Optical imaging technology in colonoscopy: Is there a role for photometric stereo?World journal of gastrointestinal endoscopy · 2020Review
- Endoscope rotating technique is useful for difficult colorectal endoscopic submucosal dissection.Surgical endoscopy · 2020Article
- Peppermint Oil to Improve Visualization in Screening Colonoscopy: A Randomized Controlled Clinical Trial.Gastroenterology research · 2019Article
- Antispasmodic Effect of Essential Oils and Their Constituents: A Review.Molecules (Basel, Switzerland) · 2019Review
- Causes of intraprocedural discomfort in colonoscopy: a review and practical tips.Therapeutic advances in gastrointestinal endoscopyReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antispasmodic drugs are cheap, effective and generally safe. They may improve outcomes in colonoscopy, however their use has not been consistent or widespread. This manuscript reviews the three most commonly used antispasmodics in colonoscopy, namely, hyoscine butylbromide (and related ammonium compounds), glucagon and peppermint oil. The pharmacology, action and safety of the agents, as well as the evidence for them improving colonoscopic outcomes will be discussed. In addition to polyp detection, other colonoscopic outcome endpoints of interest include cecal and ileal intubation, and patient comfort. The drugs studied were all found to be effective gastrointestinal antispasmodics with good safety profiles. There is insufficient evidence to conclude whether antispasmodics improve cecal intubation rate, predominantly because the baseline rates are already high. Antispasmodics probably have efficacy in reducing cecal intubation time especially in those with marked colonic spasm. Antispasmodics do not offer significant benefit in polyp detection or improving patient comfort during colonoscopy. Future studies should focus on inexperienced colonoscopists as well as those with marked colonic spasm, in whom the greatest benefit seems to lie.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.