Evidence map›Paper›PMID 28286500›Full record

ArticleFrontiers in microbiology2017

Diet-Induced Obesity Does Not Alter Tigecycline Treatment Efficacy in Murine Lyme Disease.

Helena Pětrošová, Azad Eshghi, Zoha Anjum, Nataliya Zlotnikov, Caroline E Cameron, Tara J Moriarty

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Helena PětrošováMatrix Dynamics Group, Faculty of Dentistry, University of Toronto Toronto, ON, Canada.
Azad EshghiMatrix Dynamics Group, Faculty of Dentistry, University of Toronto Toronto, ON, Canada.
Zoha AnjumMatrix Dynamics Group, Faculty of Dentistry, University of Toronto Toronto, ON, Canada.
Nataliya ZlotnikovMatrix Dynamics Group, Faculty of Dentistry, University of Toronto Toronto, ON, Canada.
Caroline E CameronDepartment of Biochemistry and Microbiology, University of Victoria Victoria, BC, Canada.
Tara J MoriartyMatrix Dynamics Group, Faculty of Dentistry, University of TorontoToronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of TorontoToronto, ON, Canada.
University of Toronto · CAUniversity of Victoria · CA

Funding

Extracellular Matrix Adhesins of Treponema pallidumR01AI051334 · NIAID · UNIVERSITY OF WASHINGTON · PI CAMERON, CAROLINE E · 2002 to 2017
$3.4M
Extracellular Matrix Adhesins of Treponema pallidumR37AI051334 · NIAID · UNIVERSITY OF VICTORIA · PI CAROLINE E CAMERON · 2019 to 2026
$2.3M
NIAID NIH HHS R01 AI051334NIAID NIH HHS R37 AI051334
6 · The paper itself

Abstract

Obese individuals more frequently suffer from infections, as a result of increased susceptibility to a number of bacterial pathogens. Furthermore, obesity can alter antibiotic treatment efficacy due to changes in drug pharmacokinetics which can result in under-dosing. However, studies on the treatment of bacterial infections in the context of obesity are scarce. To address this research gap, we assessed efficacy of antibiotic treatment in diet-induced obese mice infected with the Lyme disease pathogen,

Indexed as

antibioticsbacterial infectionBorrelia burgdorferidiet-induced obesityhumoral responseLyme diseaseobesitytigecycline

Identifiers

PMID28286500
PMCPMC5323460
OpenAlexW2590624547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.