ArticleMetabolomics : Official journal of the Metabolomic Society2017
Lipid response patterns in acute phase paediatric
Article in Metabolomics : Official journal of the Metabolomic Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Integrated lipidomic and transcriptomic profiling of the host response in human malaria.Genome biology · 2026Article
- Temporal multi-tissue profiling reveals metabolites linked to immune response and malaria parasitemia control.iScience · 2026Article
- The human malaria parasiteProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Investigation of Plasma-Derived Lipidome Profiles in Experimental Cerebral Malaria in a Mouse Model Study.International journal of molecular sciences · 2022Article
- Linking nutrient sensing and gene expression in Plasmodium falciparum blood-stage parasites.Molecular microbiology · 2021Review
- HIV-1 Impact on Malaria Transmission: A Complex and Relevant Global Health Concern.Frontiers in cellular and infection microbiology · 2021Review
- Insights into malaria pathogenesis gained from host metabolomics.PLoS pathogens · 2020Article
- Decoding the complexities of human malaria through systems immunology.Immunological reviews · 2020Review
- Alterations of Gut Microbiome and Metabolite Profiling in Mice Infected byFrontiers in immunology · 2020Article
- Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes.Nature communications · 2019Article
- Distinct amino acid and lipid perturbations characterize acute versus chronic malaria.JCI insight · 2019Article
- Insights into physiological roles of unique metabolites released from Plasmodium-infected RBCs and their potential as clinical biomarkers for malaria.Scientific reports · 2019Article
- Role of phospholipid synthesis in the development and differentiation of malaria parasites in the blood.The Journal of biological chemistry · 2018Review
- Even malaria parasites watch their host's diet.Nature microbiology · 2018Article
- Article
- Anti-malarial humoral immunity: the long and short of it.Microbes and infectionReview
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSeveral studies have observed serum lipid changes during malaria infection in humans. All of them were focused at analysis of lipoproteins, not specific lipid molecules. The aim of our study was to identify novel patterns of lipid species in malaria infected patients using lipidomics profiling, to enhance diagnosis of malaria and to evaluate biochemical pathways activated during parasite infection.
methodsUsing a multivariate characterization approach, 60 samples were representatively selected, 20 from each category (mild, severe and controls) of the 690 study participants between age of 0.5-6 years. Lipids from patient's plasma were extracted with chloroform/methanol mixture and subjected to lipid profiling with application of the LCMS-QTOF method.
resultsWe observed a structured plasma lipid response among the malaria-infected patients as compared to healthy controls, demonstrated by higher levels of a majority of plasma lipids with the exception of even-chain length lysophosphatidylcholines and triglycerides with lower mass and higher saturation of the fatty acid chains. An inverse lipid profile relationship was observed when plasma lipids were correlated to parasitaemia.
conclusionsThis study demonstrates how mapping the full physiological lipid response in plasma from malaria-infected individuals can be used to understand biochemical processes during infection. It also gives insights to how the levels of these molecules relate to acute immune responses.
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