ArticleExperimental eye research2017
Retinal accumulation of zeaxanthin, lutein, and β-carotene in mice deficient in carotenoid cleavage enzymes.
Article in Experimental eye research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Mechanism of Lutein tobioRxiv : the preprint server for biology · 2025Article
- Recent advances in carotenoid absorption, distribution, and elimination.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2025Review
- Clinical management of eye diseases: carotenoids and their nanoformulations as choice of therapeutics.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Review
- The Endless World of Carotenoids-Structural, Chemical and Biological Aspects of Some Rare Carotenoids.International journal of molecular sciences · 2023Review
- Potential roles of dietary zeaxanthin and lutein in macular health and function.Nutrition reviews · 2023Review
- Prenatal Carotenoid Supplementation With Lutein or Zeaxanthin Ameliorates Oxygen-Induced Retinopathy (OIR) in Bco2-/- Macular Pigment Mice.Investigative ophthalmology & visual science · 2023Article
- Mechanism for the selective uptake of macular carotenoids mediated by the HDL cholesterol receptor SR-BI.Experimental eye research · 2023Article
- Superior Bioavailability of a Novel Lutein and Zeaxanthin Formulation in Healthy Human Subjects.Ophthalmology and therapy · 2022Article
- Nourishing Better Vision: The ARVO 2021 Mildred Weisenfeld Award Lecture.Investigative ophthalmology & visual science · 2022Article
- HDL is the primary transporter for carotenoids from liver to retinal pigment epithelium in transgenic ApoA-IArchives of biochemistry and biophysics · 2022Article
- Mechanism of the enhancing effect of glycyrrhizin on nifedipine penetration through a lipid membrane.Journal of molecular liquids · 2021Article
- Article
- Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4Experimental eye research · 2021Article
- Carotenoids: Importance in Daily Life-Insight Gained from EPR and ENDOR.Applied magnetic resonance · 2021Review
- Overflow phenomenon in serum lutein after supplementation: a systematic review supported with SNPs analyses.International journal of ophthalmology · 2021Review
- Inverse correlation between fatty acid transport protein 4 and vision in Leber congenital amaurosis associated with RPE65 mutation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The macular carotenoids: A biochemical overview.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Review
- The Impact of Formulation on Lutein, Zeaxanthin, andAntioxidants (Basel, Switzerland) · 2020Article
- Effect of Glycyrrhizic Acid and Arabinogalactan on the Membrane Potential of Rat Thymocytes Studied by Potential-Sensitive Fluorescent Probe.The Journal of membrane biology · 2020Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
Carotenoid supplementation can prevent and reduce the risk of age-related macular degeneration (AMD) and other ocular disease, but until now, there has been no validated and well-characterized mouse model which can be employed to investigate the protective mechanism and relevant metabolism of retinal carotenoids. β-Carotene oxygenases 1 and 2 (BCO1 and BCO2) are the only two carotenoid cleavage enzymes found in animals. Mutations of the bco2 gene may cause accumulation of xanthophyll carotenoids in animal tissues, and BCO1 is involved in regulation of the intestinal absorption of carotenoids. To determine whether or not mice deficient in BCO1 and/or BCO2 can serve as a macular pigment mouse model, we investigated the retinal accumulation of carotenoids in these mice when fed with zeaxanthin, lutein, or β-carotene using an optimized carotenoid feeding method. HPLC analysis revealed that all three carotenoids were detected in sera, livers, retinal pigment epithelium (RPE)/choroids, and retinas of all of the mice, except that no carotenoid was detectable in the retinas of wild type (WT) mice. Significantly higher amounts of zeaxanthin and lutein accumulated in the retinas of BCO2 knockout (bco2
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.