Evidence map›Paper›PMID 28286175›Full record

ArticleDevelopmental biology2017

Cilia-dependent GLI processing in neural crest cells is required for tongue development.

Grethel Millington, Kelsey H Elliott, Ya-Ting Chang, Ching-Fang Chang, Andrzej Dlugosz, Samantha A Brugmann

Abstract read
In one paragraph

Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Frontiers in cell and developmental biology · 2026
    Article
  3. A dual role for GLI3 signaling in neural crest development.Development (Cambridge, England) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Augmented BMP4 signal impairs tongue myogenesis.Journal of molecular histology · 2021
    Article
  13. Review
  14. Article
  15. Investigating Primary Cilia during Peripheral Nervous System Formation.International journal of molecular sciences · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Grethel MillingtonDivision of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
Kelsey H ElliottDivision of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
Ya-Ting ChangDivision of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
Ching-Fang ChangDivision of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
Andrzej DlugoszDepartment of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, United States.
Samantha A BrugmannDivision of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States. Electronic address: samantha.brugmann@cchmc.org.
Cincinnati Children's Hospital Medical Center · USUniversity of Michigan · US

Funding

TRAINING PROGRAM IN TERATOLOGYT32ES007051 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI VORHEES, CHARLES V · 1985 to 2018
$4.1M
The Role of Primary Cilia in Murine Craniofacial DevelopmentR01DE023804 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI BRUGMANN, SAMANTHA A · 2014 to 2017
$1.6M
NIDCR NIH HHS R01 DE023804NIEHS NIH HHS T32 ES007051
6 · The paper itself

Abstract

Ciliopathies are a class of diseases caused by the loss of a ubiquitous, microtubule-based organelle called a primary cilium. Ciliopathies commonly result in defective development of the craniofacial complex, causing midfacial defects, craniosynostosis, micrognathia and aglossia. Herein, we explored how the conditional loss of primary cilia on neural crest cells (Kif3a

Indexed as

AnimalsApoptosisCell MovementCiliaGene DeletionHedgehog ProteinsIntegrasesKinesinsKruppel-Like Transcription FactorsMandibleMesodermMiceModels, BiologicalMusclesMutationNerve Tissue ProteinsCre recombinaseGli2 protein, mouseGli3 protein, mouseHedgehog ProteinsIntegrasesKif3a protein, mouseKinesinsKruppel-Like Transcription FactorsNerve Tissue ProteinsWnt1 ProteinZinc Finger Protein Gli2Zinc Finger Protein Gli3AglossiaCiliopathiesCraniofacialGliMouseNeural crest cellPrimary ciliaSonic HedgehogTongue development

Identifiers

PMID28286175
PMCPMC5420199
OpenAlexW2592367605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.