ArticleHearing research2017
Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress.
Article in Hearing research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Map plasticity following noise exposure in auditory cortex of rats: implications for disentangling neural correlates of tinnitus and hyperacusis.Frontiers in neuroscience · 2024Article
- Identifying tinnitus in mice by tracking the motion of body markers in response to an acoustic startle.Frontiers in neuroscience · 2024Article
- Assessing the impact of sleep restriction on the attention and executive functions of medical students: a prospective cohort study.Acta neurologica Belgica · 2023Article
- Longitudinal Study of Analgesic Use and Risk of Incident Persistent Tinnitus.Journal of general internal medicine · 2022Article
- Clinical Findings That Differentiate Co-Occurrence of Hyperacusis and Tinnitus from Tinnitus Alone.Yonsei medical journal · 2022Article
- Altered resting-state functional connectivity of the anterior cingulate cortex in rats post noise exposure.CNS neuroscience & therapeutics · 2022Article
- Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus.Frontiers in aging neuroscience · 2022Article
- Role of the caudate-putamen nucleus in sensory gating in induced tinnitus in rats.Neural regeneration research · 2021Article
- Review: Neural Mechanisms of Tinnitus and Hyperacusis in Acute Drug-Induced Ototoxicity.American journal of audiology · 2021Review
- Functional Neuroanatomy of Salicylate- and Noise-Induced Tinnitus and Hyperacusis.Current topics in behavioral neurosciences · 2021Article
- Functional magnetic resonance imaging of enhanced central auditory gain and electrophysiological correlates in a behavioral model of hyperacusis.Hearing research · 2020Article
- Noise-Induced loudness recruitment and hyperacusis: Insufficient central gain in auditory cortex and amygdala.Neuroscience · 2019Article
- Noise-induced hearing loss: Translating risk from animal models to real-world environments.The Journal of the Acoustical Society of America · 2019Review
- Testing the Central Gain Model: Loudness Growth Correlates with Central Auditory Gain Enhancement in a Rodent Model of Hyperacusis.Neuroscience · 2019Article
- Aberrant thalamocortical coherence in an animal model of tinnitus.Journal of neurophysiology · 2019Article
- Increased Resting-State Cerebellar-Cerebral Functional Connectivity Underlying Chronic Tinnitus.Frontiers in aging neuroscience · 2018Article
- One-Year Results for Patients with Unilateral Hearing Loss and Accompanying Severe Tinnitus and Hyperacusis Treated with a Cochlear Implant.Audiology & neuro-otology · 2018Article
- Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss.Neural plasticity · 2018Article
- Noise-induced hearing loss induces loudness intolerance in a rat Active Sound Avoidance Paradigm (ASAP).Hearing research · 2017Article
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Tinnitus and hyperacusis are common and potentially serious hearing disorders associated with noise-, age- or drug-induced hearing loss. Accumulating evidence suggests that tinnitus and hyperacusis are linked to excessive neural activity in a distributed brain network that not only includes the central auditory pathway, but also brain regions involved in arousal, emotion, stress and motor control. Here we examine electrophysiological changes in two novel non-auditory areas implicated in tinnitus and hyperacusis: the caudal pontine reticular nucleus (PnC), involved in arousal, and the paraflocculus lobe of the cerebellum (PFL), implicated in head-eye coordination and gating tinnitus and we measure the changes in corticosterone stress hormone levels. Using the salicylate-induced model of tinnitus and hyperacusis, we found that long-latency (>10 ms) sound-evoked response components in both the brain regions were significantly enhanced after salicylate administration, while the short-latency responses were reduced, likely reflecting cochlear hearing loss. These results are consistent with the central gain model of tinnitus and hyperacusis, which proposes that these disorders arise from the amplification of neural activity in central auditory pathway plus other regions linked to arousal, emotion, tinnitus gating and motor control. Finally, we demonstrate that salicylate results in an increase in corticosterone level in a dose-dependent manner consistent with the notion that stress may interact with hearing loss in tinnitus and hyperacusis development. This increased stress response has the potential to have wide-ranging effects on the central nervous system and may therefore contribute to brain-wide changes in neural activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.