Evidence map›Paper›PMID 28285835›Full record

ReviewTrends in biochemical sciences2017

Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances.

Sarah F Pearce, Pedro Rebelo-Guiomar, Aaron R D'Souza, Christopher A Powell, Lindsey Van Haute, Michal Minczuk

Open access · hybridAbstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 184 citations in OpenAlex.

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  7. Light Metabolically Reprograms CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  20. Mechanisms and regulation of human mitochondrial transcription.Nature reviews. Molecular cell biology · 2024
    Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sarah F PearceMitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Pedro Rebelo-GuiomarMitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK; Graduate Program in Areas of Basic and Applied Biology (GABBA), University of Porto, Porto, Portugal.
Aaron R D'SouzaMitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Christopher A PowellMitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Lindsey Van HauteMitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Michal MinczukMitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK. Electronic address: michal.minczuk@mrc-mbu.cam.ac.uk.
MRC Mitochondrial Biology Unit · GBUniversidade do Porto · PT

Funding

Medical Research Council MC_U105697135Medical Research Council MC_UU_00015/4
6 · The paper itself

Abstract

Perturbation of mitochondrial DNA (mtDNA) gene expression can lead to human pathologies. Therefore, a greater appreciation of the basic mechanisms of mitochondrial gene expression is desirable to understand the pathophysiology of associated disorders. Although the purpose of the mitochondrial gene expression machinery is to provide only 13 proteins of the oxidative phosphorylation (OxPhos) system, recent studies have revealed its remarkable and unexpected complexity. We review here the latest breakthroughs in our understanding of the post-transcriptional processes of mitochondrial gene expression, focusing on advances in analyzing the mitochondrial epitranscriptome, the role of mitochondrial RNA granules (MRGs), the benefits of recently obtained structures of the mitochondrial ribosome, and the coordination of mitochondrial and cytosolic translation to orchestrate the biogenesis of OxPhos complexes.

Indexed as

Oxidative PhosphorylationAnimalsGene Expression RegulationGenes, MitochondrialHumansMitochondriaMitochondrial RibosomesRNA Processing, Post-Transcriptional

Identifiers

PMID28285835
PMCPMC5538620
OpenAlexW2592267203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.