Evidence map›Paper›PMID 28285748›Full record

ArticleJournal of biomechanics2017

A modelling approach demonstrating micromechanical changes in the tibial cemented interface due to in vivo service.

Priyanka Srinivasan, Mark A Miller, Nico Verdonschot, Kenneth A Mann, Dennis Janssen

Abstract read
In one paragraph

Article in Journal of biomechanics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Priyanka SrinivasanRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands. Electronic address: priyanka.srinivasan@radboudumc.nl.
Mark A MillerDepartment of Orthopedic Surgery, State University of New York, Upstate Medical University, Syracuse, NY, USA.
Nico VerdonschotRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands; University of Twente, Laboratory for Biomechanical Engineering, Faculty of Engineering Technology, Enschede, The Netherlands.
Kenneth A MannDepartment of Orthopedic Surgery, State University of New York, Upstate Medical University, Syracuse, NY, USA.
Dennis JanssenRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Funding

INTERFACE FAILURE IN TOTAL JOINT REPLACEMENTSR01AR042017 · NIAMS · UPSTATE MEDICAL UNIVERSITY · PI MANN, KENNETH A. · 2001 to 2021
$6.3M
INTERFACE FAILURE IN TOTAL JOINT REPLACEMENTSR29AR042017 · NIAMS · UPSTATE MEDICAL UNIVERSITY · PI MANN, KENNETH A. · 1996 to 2000
$68k
NIAMS NIH HHS R01 AR042017NIAMS NIH HHS R29 AR042017
6 · The paper itself

Abstract

Post-operative changes in trabecular bone morphology at the cement-bone interface can vary depending on time in service. This study aims to investigate how micromotion and bone strains change at the tibial bone-cement interface before and after cementation. This work discusses whether the morphology of the post-mortem interface can be explained by studying changes in these mechanical quantities. Three post-mortem cement-bone interface specimens showing varying levels of bone resorption (minimal, extensive and intermediate) were selected for this study Using image segmentation techniques, masks of the post-mortem bone were dilated to fill up the mould spaces in the cement to obtain the immediately post-operative situation. Finite element (FE) models of the post-mortem and post-operative situation were created from these segmentation masks. Subsequent removal of the cement layer resulted in the pre-operative situation. FE micromotion and bone strains were analyzed for the interdigitated trabecular bone. For all specimens micromotion increased from the post-operative to the post-mortem models (distally, in specimen 1: 0.1 to 0.5µm; specimen 2: 0.2 to 0.8µm; specimen 3: 0.27 to 1.62µm). Similarly bone strains were shown to increase from post-operative to post-mortem (distally, in specimen 1: -185 to -389µε; specimen 2: -170 to -824µε; specimen 3: -216 to -1024µε). Post-mortem interdigitated bone was found to be strain shielded in comparison with supporting bone indicating that failure of bone would occur distal to the interface. These results indicate that stress shielding of interdigitated trabeculae is a plausible explanation for resorption patterns observed in post-mortem specimens.

Indexed as

Bone CementsModels, TheoreticalAged, 80 and overBone ResorptionCementationFemaleFinite Element AnalysisHumansMaleMiddle AgedMovementStress, MechanicalTibiaBone CementsBone–cement interfaceBone strainFinite element analysisMicromotionTibial loosening

Identifiers

PMID28285748
PMCPMC5393929

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.