ArticleMetabolism: clinical and experimental2017
Correlation of metabolic syndrome severity with cardiovascular health markers in adolescents.
Article in Metabolism: clinical and experimental, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Trial
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- Beyond Discrete Diagnoses: Conceptualizing Obesity-associated Metabolic Disorders as a Unified, Dynamic Continuum.Current obesity reports · 2025Review
- BMI trajectory and inflammatory effects on metabolic syndrome in adolescents.Pediatric research · 2023Article
- The association of sagittal abdominal diameter with metabolic syndrome risk before and after weight-loss surgery in adolescents.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2023Article
- Relationship between serum uric acid and estimated glomerular filtration rate in adolescents aged 12-19 years with different body mass indices: a cross-sectional study.Frontiers in endocrinology · 2023Article
- The Presence of Hyperhomocysteinemia Does Not Aggravate the Cardiometabolic Risk Imposed by Hyperuricemia in Young Individuals: A Retrospective Analysis of a Cross-Sectional Study.International journal of environmental research and public health · 2022Article
- Effect of Sprint Interval Training on Cardiometabolic Biomarkers and Adipokine Levels in Adolescent Boys with Obesity.International journal of environmental research and public health · 2022Article
- Cardiovascular Risk Factors and Target Organ Damage in Adolescents: The SHIP AHOY Study.Pediatrics · 2022Article
- Association of diet quality, physical activity, and abdominal obesity with metabolic syndrome z-score in black and white adolescents in the US.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2022Article
- Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence.Scientific reports · 2021Article
- Metabolic risk associated with liver enzymes, uric acid, and hemoglobin in adolescents.Pediatric research · 2020Article
- Asymptomatic Hyperuricemia Associates with Cardiometabolic Risk Indicators in Overweight/Obese but Not in Lean Adolescents.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Food Insecurity Is Associated with Prediabetes Risk Among U.S. Adolescents, NHANES 2003-2014.Metabolic syndrome and related disorders · 2019Article
- Metabolic syndrome severity and lifestyle factors among adolescents.Minerva pediatrica · 2018Review
- Longitudinal Associations of Metabolic Syndrome Severity Between Childhood and Young Adulthood: The Bogalusa Heart Study.Metabolic syndrome and related disorders · 2018Article
- Use of BMI as the marker of adiposity in a metabolic syndrome severity score: Derivation and validation in predicting long-term disease outcomes.Metabolism: clinical and experimental · 2018Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesThe presence of metabolic syndrome (MetS) in childhood is a significant risk factor for later cardiovascular disease (CVD). Recent data showed temporal decreases in a sex- and race/ethnicity-specific MetS severity z-score among U.S. adolescents. Our goal was to characterize the relationship of this MetS z-score with other CVD risk indicators and assess their temporal trends and lifestyle influences.
methodsWe analyzed 4837 participants aged 12-20years from the National Health and Nutrition Examination Survey by 2-year waves from 1999 to 2012. We used linear regression to compare MetS z-score and dietary factors with serum levels of low-density lipoprotein (LDL), apolipoprotein-B (ApoB), high-sensitivity C-reactive protein (hsCRP) and uric acid.
resultsMetS severity z-score was positively correlated with LDL, ApoB, hsCRP, and uric acid measurements (p<0.0001 for all). These correlations held true among individual racial/ethnic groups. LDL, ApoB, and hsCRP measurements decreased over time among U.S. adolescents (p=0.002, p<0.0001, and p=0.024, respectively). Saturated fat consumption was positively correlated with LDL (p=0.005) and ApoB (p=0.012) and inversely related to serum uric acid (p=0.001). Total caloric intake was inversely related to LDL (p=0.003) and serum uric acid (p=0.003). Unsaturated fat, carbohydrate, and protein consumption were not related to LDL, ApoB, hsCRP, or serum uric acid.
conclusionsThere is a positive correlation between MetS severity and all four CVD risk indicators studied. LDL, ApoB, and hsCRP showed favorable temporal trends, which could be related to similar trends in MetS z-score. These data support the importance of considering multiple inter-related factors in clinical CVD risk assessment.
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