Evidence map›Paper›PMID 28285432›Full record

Trial reportEuropean journal of nutrition2018

A low-dose, 6-week bovine colostrum supplementation maintains performance and attenuates inflammatory indices following a Loughborough Intermittent Shuttle Test in soccer players.

Yiannis Kotsis, Anastasia Mikellidi, Cleopatra Aresti, Eleni Persia, Aristomenis Sotiropoulos, Demosthenes B Panagiotakos, Smaragdi Antonopoulou, Tzortzis Nomikos

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  3. Bovine colostrum supplementation in rugby.European journal of applied physiology · 2026
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  5. DoesNutrients · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yiannis KotsisDepartment of Nutrition and Dietetics, Faculty of Health Sciences and Education, Harokopio University, Eleftheriou Venizelou 70, 17671, Athens, Greece.
Anastasia MikellidiDepartment of Nutrition and Dietetics, Faculty of Health Sciences and Education, Harokopio University, Eleftheriou Venizelou 70, 17671, Athens, Greece.
Cleopatra ArestiDepartment of Nutrition and Dietetics, Faculty of Health Sciences and Education, Harokopio University, Eleftheriou Venizelou 70, 17671, Athens, Greece.
Eleni PersiaDepartment of Nutrition and Dietetics, Faculty of Health Sciences and Education, Harokopio University, Eleftheriou Venizelou 70, 17671, Athens, Greece.
Aristomenis SotiropoulosFaculty of Physical Education and Sport Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Demosthenes B PanagiotakosDepartment of Nutrition and Dietetics, Faculty of Health Sciences and Education, Harokopio University, Eleftheriou Venizelou 70, 17671, Athens, Greece.
Smaragdi AntonopoulouDepartment of Nutrition and Dietetics, Faculty of Health Sciences and Education, Harokopio University, Eleftheriou Venizelou 70, 17671, Athens, Greece.
Tzortzis NomikosDepartment of Nutrition and Dietetics, Faculty of Health Sciences and Education, Harokopio University, Eleftheriou Venizelou 70, 17671, Athens, Greece. tnomikos@hua.gr.ORCID http://orcid.org/0000-0003-0536-6397
Harokopio University of Athens · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of the study was to investigate the effect of a 6-week, low-dose bovine colostrum (BC) supplementation on exercise-induced muscle damage (EIMD) and performance decline in soccer players following the Loughborough Intermittent Shuttle Test (LIST) during a competitive season period.

methodsIn a double-blind, randomized, placebo-controlled design, two groups of soccer players were allocated to a 3.2 g/day of whey protein (WP, N = 8) or BC (N = 10) and performed a pre- and a post-supplementation LIST. Maximum isometric voluntary contraction, squat jump (SQJ), countermovement jump, muscle soreness, blood cell counts, creatine kinase (CK), C-reactive protein (CRP) and interleukin-6 (IL-6) were monitored for 2, 24, 48, 72 h post-LIST.

resultsLIST induced transient increases in leukocytes, granulocytes, CK, muscle soreness, CRP, IL-6 and declines in lymphocytes and performance indices. Supplementation resulted in a faster recovery of SQJ, CK and CRP compared to pre-supplementation kinetics (trial × time: p = 0.001, 0.056, 0.014, respectively) and lower incremental area under the curve (iAUC) for IL-6, only in the BC group [pre-: 31.1 (6.78-46.9), post-: 14.0 (-0.16 to 23.5) pg h/ml, p = 0.034]. Direct comparison of the two groups after supplementation demonstrated higher iAUC of SQJ [WP: -195.2 (-229.0 to (-52.5)), BC: -15.8 (-93.2 to 16.8) cm h, p = 0.034], a trend for lower iAUC of CK in the BC group [WP: 18,785 (4651-41,357), BC: 8842 (4807-14,802) U h/L, p = 0.081] and a significant intervention × time interaction for CRP (p = 0.038) in favor of BC.

conclusionsPost-exercise EIMD may be reduced and performance better maintained by a low dose of BC administration following LIST in soccer players.

Indexed as

AthletesColostrumDietary SupplementsSports Nutritional Physiological PhenomenaAdultAnimalsAthletic PerformanceBiomarkersCattleC-Reactive ProteinDouble-Blind MethodExercise TestGreeceHumansImmunosuppressive AgentsInterleukin-6BiomarkersC-Reactive ProteinIL6 protein, humanImmunosuppressive AgentsInterleukin-6Performance-Enhancing SubstancesWhey ProteinsBovine colostrumExercise-induced muscle damageInflammationLoughborough Intermittent Shuttle TestSoccerSquat jump

Identifiers

PMID28285432
PMCPMC5861165
OpenAlexW2594173201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.