Evidence map›Paper›PMID 28285422›Full record

ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2017

Current and future techniques for human papilloma virus (HPV) testing in oropharyngeal squamous cell carcinoma.

Ali Qureishi, Thomas Mawby, Lisa Fraser, Ketan A Shah, Henrik Møller, Stuart Winter

Abstract readReview
PubMed Publisher
In one paragraph

Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Human papillomavirus testing in metastatic squamous cell carcinoma of the neck with unknown primary using PCR on fine-needle aspiration smears: a prospective clinical study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Update on oral and oropharyngeal cancer staging - International perspectives.World journal of otorhinolaryngology - head and neck surgery · 2020
    Review
  10. Article
  11. Review
  12. Article
  13. Letter to editor: Current and future techniques for human papilloma virus (HPV) testing in oropharyngeal squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
    Article
  14. Microarray technology for identification of human papilloma virus subtype in oropharyngeal squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
    Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ali QureishiDepartment of Otolaryngology, Oxford University Hospitals NHS Trust, Oxford, England. aliqureishi@googlemail.com.
Thomas MawbyDepartment of Otolaryngology, Oxford University Hospitals NHS Trust, Oxford, England.
Lisa FraserDepartment of Otolaryngology, Oxford University Hospitals NHS Trust, Oxford, England.
Ketan A ShahDepartment of Histopathology, Oxford University Hospitals NHS Trust, Oxford, England.
Henrik MøllerCancer Epidemiology and Population Health, Kings College London, London, UK.
Stuart WinterDepartment of Otolaryngology, Oxford University Hospitals NHS Trust, Oxford, England.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite a reduction in smoking and alcohol consumption, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rising. This is attributed to human papilloma virus (HPV) infection and screening for HPV is now recommended in all cases of OPSCC. Despite a variety of clinically available tests and new non-invasive test strategies there is no consensus on which technique is best. This review reports on current techniques for HPV detection in OPSCC and the clinical applicability of emerging techniques. Literature searches of Medline, Embase and clinicaltrials.gov using the search terms 'head and neck neoplasms', 'squamous cell carcinoma' and 'HPV testing' were performed. 45 studies were identified and included. p16 immunohistochemistry (IHC), HPV DNA in situ hybridization (ISH) and HPV polymerase chain reaction (PCR) are the commonest tests to determine HPV status. p16 IHC and HPV DNA PCR are highly sensitive whilst HPV DNA ISH is more specific, these techniques conventionally utilize surgical biopsies. New tests using PCR to screen fine needle aspirates, saliva, brush cytology and serum for HPV are promising but have variable sensitivity and specificity. These non-invasive samples avoid the morbidity of surgical biopsies and need for tissue blocks; their clinical role in screening and surveillance remains largely untested. Further work is needed to validate these tests and define their role.

Indexed as

Biomarkers, TumorBiopsy, Fine-NeedleCarcinoma, Squamous CellDNA, ViralHumansImmunohistochemistryIn Situ HybridizationOropharyngeal NeoplasmsPapillomaviridaePapillomavirus InfectionsPolymerase Chain ReactionSalivaSensitivity and SpecificityBiomarkers, TumorDNA, ViralHPVImmunohistochemistryIn-situ hybridisationLiquid-biopsyOropharyngeal SCCPCR

Identifiers

PMID28285422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.