ArticlePsychiatry research. Neuroimaging2017
Gender dimorphism of brain reward system volumes in alcoholism.
Article in Psychiatry research. Neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Not just neurons: glial mechanisms driving sex-specific vulnerability to withdrawal and relapse in substance use disorder.Frontiers in neuroendocrinology · 2026Review
- Alcohol Cues Elicit Differences in Brain Activation Patterns of Abstinent Men and Women with Alcohol Use Disorders.Neuropsychiatric disease and treatment · 2026Article
- Sex and sobriety: Human brain structure and function in AUD abstinence.Alcohol (Fayetteville, N.Y.) · 2024Review
- Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence.Alcohol, clinical & experimental research · 2024Article
- Astrocyte Reactivity and Neurodegeneration in the Female Rat Brain Following Alcohol Dependence.Neuroscience · 2023Article
- Brain volumes in alcohol use disorder: Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis.Human brain mapping · 2023Article
- Dose-dependent relationship between social drinking and brain aging.Neurobiology of aging · 2022Article
- Intrinsic brain functional connectivity patterns in alcohol use disorder.Brain communications · 2022Article
- Alcohol use and interoception - A narrative review.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Evaluating effects of sex and age on white matter microstructural alterations in alcohol use disorder: A diffusion tensor imaging study.Alcoholism, clinical and experimental research · 2021Article
- Regionally specific gray matter volume is lower in alcohol use disorder: Implications for noninvasive brain stimulation treatment.Alcoholism, clinical and experimental research · 2021Article
- Brain, behavioral, affective, and sex correlates of recovery from alcohol use disorders.Alcoholism, clinical and experimental research · 2021Article
- Accelerated Aging of the Amygdala in Alcohol Use Disorders: Relevance to the Dark Side of Addiction.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.PloS one · 2021Article
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Journal of neuroscience research · 2021Review
- Sex-specific associations between subcortical morphometry in childhood and adult alcohol consumption: A 17-year follow-up study.NeuroImage. Clinical · 2021Article
- Sex Differences in Substance Use Disorders: A Neurobiological Perspective.Frontiers in global women's health · 2021Review
- Chronic Pain in Relation to Depressive Disorders and Alcohol Abuse.Brain sciences · 2020Article
- Males are more sensitive to reward and less sensitive to loss than females among people with internet gaming disorder: fMRI evidence from a card-guessing task.BMC psychiatry · 2020Article
- Cerebellar Morphometry and Cognition in the Context of Chronic Alcohol Consumption and Cigarette Smoking.Alcoholism, clinical and experimental research · 2020Article
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Authors and funding
6 authors.
Funding
Abstract
The brain's reward network has been reported to be smaller in alcoholic men compared to nonalcoholic men, but little is known about the volumes of reward regions in alcoholic women. Morphometric analyses were performed on magnetic resonance brain scans of 60 long-term chronic alcoholics (ALC; 30 men) and 60 nonalcoholic controls (NC; 29 men). We derived volumes of total brain, and cortical and subcortical reward-related structures including the dorsolateral prefrontal (DLPFC), orbitofrontal, and cingulate cortices, and the temporal pole, insula, amygdala, hippocampus, nucleus accumbens septi (NAc), and ventral diencephalon (VDC). We examined the relationships of the volumetric findings to drinking history. Analyses revealed a significant gender interaction for the association between alcoholism and total reward network volumes, with ALC men having smaller reward volumes than NC men and ALC women having larger reward volumes than NC women. Analyses of a priori subregions revealed a similar pattern of reward volume differences with significant gender interactions for DLPFC and VDC. Overall, the volume of the cerebral ventricles in ALC participants was negatively associated with duration of abstinence, suggesting decline in atrophy with greater length of sobriety.
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