Evidence map›Paper›PMID 28285189›Full record

ArticleRedox biology2017

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve.

Zsolt Radak, Kazunari Ishihara, Eva Tekus, Csaba Varga, Aniko Posa, Laszlo Balogh, Istvan Boldogh, Erika Koltai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zsolt RadakResearch Institute of Sport Science, University of Physical Education, Budapest, Hungary. Electronic address: radak@tf.hu.
Kazunari IshiharaResearch Institute of Sport Science, University of Physical Education, Budapest, Hungary.
Eva TekusInstitute of Sport Science and Physical Education, University of Pecs, Pecs, Hungary.
Csaba VargaDepartment of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.
Aniko PosaDepartment of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.
Laszlo BaloghInstitute of Sport Science, University of Debrecen, Debrecen, Hungary.
Istvan BoldoghDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Erika KoltaiResearch Institute of Sport Science, University of Physical Education, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is debated whether exercise-induced ROS production is obligatory to cause adaptive response. It is also claimed that antioxidant treatment could eliminate the adaptive response, which appears to be systemic and reportedly reduces the incidence of a wide range of diseases. Here we suggest that if the antioxidant treatment occurs before the physiological function-ROS dose-response curve reaches peak level, the antioxidants can attenuate function. On the other hand, if the antioxidant treatment takes place after the summit of the bell-shaped dose response curve, antioxidant treatment would have beneficial effects on function. We suggest that the effects of antioxidant treatment are dependent on the intensity of exercise, since the adaptive response, which is multi pathway dependent, is strongly influenced by exercise intensity. It is further suggested that levels of ROS concentration are associated with peak physiological function and can be extended by physical fitness level and this could be the basis for exercise pre-conditioning. Physical inactivity, aging or pathological disorders increase the sensitivity to oxidative stress by altering the bell-shaped dose response curve.

Indexed as

AntioxidantsExerciseHormesisHumansOxidantsOxidative StressPhysical FitnessReactive Oxygen SpeciesAntioxidantsOxidantsReactive Oxygen Species

Identifiers

PMID28285189
PMCPMC5345970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.