Evidence map›Paper›PMID 28285038›Full record

ArticleThe Journal of arthroplasty2017

Peri-Implant Distribution of Polyethylene Debris in Postmortem-Retrieved Knee Arthroplasties: Can Polyethylene Debris Explain Loss of Cement-Bone Interlock in Successful Total Knee Arthroplasties?

Karen I Cyndari, Jacklyn R Goodheart, Mark A Miller, Megan E Oest, Timothy A Damron, Kenneth A Mann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of arthroplasty, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Similitude of cement-bone micromechanics in cemented rat and human knee replacement.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karen I CyndariDepartment of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.
Jacklyn R GoodheartDepartment of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.
Mark A MillerDepartment of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.
Megan E OestDepartment of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.
Timothy A DamronDepartment of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.
Kenneth A MannDepartment of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.

Funding

INTERFACE FAILURE IN TOTAL JOINT REPLACEMENTSR01AR042017 · NIAMS · UPSTATE MEDICAL UNIVERSITY · PI MANN, KENNETH A. · 2001 to 2021
$6.3M
Supraphysiologic Fluid Shear Stress as an Alternative Cause of Short-term Aseptic Loosening in Total Knee ReplacementsF30AR067570 · NIAMS · UPSTATE MEDICAL UNIVERSITY · PI CYNDARI, KAREN I · 2015 to 2018
$162k
NIAMS NIH HHS F30 AR067570NIAMS NIH HHS R01 AR042017
6 · The paper itself

Abstract

backgroundLoss of mechanical interlock between cement and bone with in vivo service has been recently quantified for functioning, nonrevised, cemented total knee arthroplasties (TKAs). The cause of interlocking trabecular resorption is not known. The goal of this study is to quantify the distribution of PE debris at the cement-bone interface and determine if polyethylene (PE) debris is locally associated with loss of interlock.

methodsFresh, nonrevised, postmortem-retrieved TKAs (n = 8) were obtained en bloc. Laboratory-prepared constructs (n = 2) served as negative controls. The intact cement-bone interface of each proximal tibia was embedded in Spurr's resin, sectioned, and imaged under polarized light to identify birefringent PE particles. PE wear particle number density was quantified at the cement-bone interface and distal to the interface, and then compared with local loss of cement-bone interlock.

resultsThe average PE particle number density for postmortem-retrieved TKAs ranged from 8.6 (1.3) to 24.9 (3.1) particles/mm

conclusionPE debris can migrate extensively along the cement-bone interface of well-fixed tibial components. However, the amount of local bone loss at the cement-bone interface was not correlated with the amount of PE debris at the interface, suggesting that the observed loss of trabecular interlock in these well-fixed TKAs may be due to alternative factors.

Indexed as

Bone-Implant InterfacePolyethyleneProsthesis FailureAdultAgedAged, 80 and overArthroplasty, Replacement, KneeBone CementsBone ResorptionFemaleHumansKneeMaleMiddle AgedProstheses and ImplantsTibiaBone CementsPolyethyleneaseptic looseningpolyethylene debrispostmortem retrievaltotal knee arthroplastyultra-high-molecular-weight polyethylene

Identifiers

PMID28285038
PMCPMC5469692

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.