Evidence map›Paper›PMID 28284952›Full record

ArticleBehavioural brain research2017

Importance of D1 and D2 receptor stimulation for the induction and expression of cocaine-induced behavioral sensitization in preweanling rats.

Sanders A McDougall, Krista N Rudberg, Ana Veliz, Janhavi M Dhargalkar, Aleesha S Garcia, Loveth C Romero, Ashley E Gonzalez, Alena Mohd-Yusof, Cynthia A Crawford

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In one paragraph

Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sanders A McDougallDepartment of Psychology, California State University, San Bernardino, CA, USA. Electronic address: smcdouga@csusb.edu.
Krista N RudbergDepartment of Psychology, California State University, San Bernardino, CA, USA.
Ana VelizDepartment of Psychology, California State University, San Bernardino, CA, USA.
Janhavi M DhargalkarDepartment of Psychology, California State University, San Bernardino, CA, USA.
Aleesha S GarciaDepartment of Psychology, California State University, San Bernardino, CA, USA.
Loveth C RomeroDepartment of Psychology, California State University, San Bernardino, CA, USA.
Ashley E GonzalezDepartment of Psychology, California State University, San Bernardino, CA, USA; Neuroscience Program, Stanford University School of Medicine, Stanford, CA, USA.
Alena Mohd-YusofDepartment of Psychology, California State University, San Bernardino, CA, USA.
Cynthia A CrawfordDepartment of Psychology, California State University, San Bernardino, CA, USA.

Funding

CSU San Bernardino Minority Access to Research CareersT34GM083883 · NIGMS · CALIFORNIA STATE UNIV SAN BERNARDINO · PI MCDOUGALL, SANDERS · 2009 to 2019
$3.0M
CSUSB - DIDARPR24DA033877 · NIDA · CALIFORNIA STATE UNIV SAN BERNARDINO · PI CRAWFORD, CYNTHIA A. · 2012 to 2016
$2.1M
Ontogeny of caudate-putamen functioning: behavioral relevanceSC1MH102930 · NIMH · CALIFORNIA STATE UNIV SAN BERNARDINO · PI MCDOUGALL, SANDERS · 2013 to 2016
$1.4M
NIDA NIH HHS R24 DA033877NIGMS NIH HHS T34 GM083883NIMH NIH HHS SC1 MH102930
6 · The paper itself

Abstract

The behavioral manifestations of psychostimulant-induced sensitization vary markedly between young and adult rats, suggesting that the neural mechanisms mediating this phenomenon differ across ontogeny. In this project we examined the importance of D1 and D2 receptors for the induction and expression of cocaine-induced behavioral sensitization during the preweanling period. In the behavioral experiments, rats were injected with reversible D1 and/or D2 antagonists (SCH23390 and/or raclopride) or an irreversible receptor antagonist (EEDQ) either before cocaine administration on the pretreatment day (induction) or before cocaine challenge on the test day (expression). In the EEDQ experiments, receptor specificity was assessed by using selective dopamine antagonists to protect D1 and/or D2 receptors from inactivation. Receptor binding assays showed that EEDQ caused substantial reductions in dorsal striatal D1 and D2 binding sites, while SCH23390 and raclopride fully protected D1 and D2 receptors from EEDQ-induced alkylation. Behavioral results showed that neither D1 nor D2 receptor stimulation was necessary for the induction of cocaine sensitization in preweanling rats. EEDQ disrupted the sensitization process, suggesting that another receptor type sensitive to EEDQ alkylation was necessary for the induction process. Expression of the sensitized response was prevented by an acute injection of a D1 receptor antagonist. The pattern of DA antagonist-induced effects described for preweanling rats is, with few exceptions, similar to what is observed when the same drugs are administered to adult rats. Thus, it appears that maturational changes in D1 and D2 receptor systems are not responsible for ontogenetic differences in the behavioral manifestation of cocaine sensitization.

Indexed as

Age FactorsAnimalsBehavior, AnimalBenzazepinesCentral Nervous System SensitizationCocaineDopamine AntagonistsDopamine D2 Receptor AntagonistsDopamine Uptake InhibitorsFemaleNeostriatumQuinolinesRacloprideRatsRats, Sprague-DawleyReceptors, Dopamine D1BenzazepinesCocaineDopamine AntagonistsDopamine D2 Receptor AntagonistsDopamine Uptake InhibitorsEEDQQuinolinesRacloprideReceptors, Dopamine D1Receptors, Dopamine D2SCH 23390Behavioral sensitizationCocaineEEDQOntogenyRacloprideSCH23390

Identifiers

PMID28284952
PMCPMC5422209

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.