Evidence map›Paper›PMID 28284819›Full record

ArticleEnvironment international2017

Associations between long-term exposure to PM

Jamaji C Nwanaji-Enwerem, Lingzhen Dai, Elena Colicino, Youssef Oulhote, Qian Di, Itai Kloog, Allan C Just, Lifang Hou, Pantel Vokonas, Andrea A Baccarelli and 2 more

Open access · greenAbstract read
In one paragraph

Article in Environment international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 5 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Ambient PMEnvironmental geochemistry and health · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Jamaji C Nwanaji-EnweremDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: jnwanajienwerem@g.harvard.edu.
Lingzhen DaiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Elena ColicinoDepartment of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA.
Youssef OulhoteDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Qian DiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Itai KloogDepartment of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Allan C JustDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lifang HouDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Pantel VokonasVA Normative Aging Study, Veterans Affairs Boston Healthcare System, The Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA.
Marc G WeisskopfDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Joel D SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USColumbia University · USBen-Gurion University of the Negev · ILBoston University · USIcahn School of Medicine at Mount Sinai · USNorthwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2014 to 2026
$21.3M
Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging CohortR01ES015172 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2006 to 2015
$4.8M
Circulating microRNAs in Extracellular Vesicles, Air Particulate Pollution, and Lung Function in an Aging CohortR01ES025225 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BACCARELLI, ANDREA · 2016 to 2020
$2.9M
Molecular and Epigenetic Mitochondriomics of Air Particles, Lead and CognitionR01ES021733 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2012 to 2015
$2.4M
Cardiovascular Effects of Particles:The Role of Oxidative Stress and Metal PathwR01ES014663 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2008 to 2011
$1.9M
Prenatal Exposure to Endocrine Disrupters, DNA Methylation, and Childhood ObesityR00ES023450 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JUST, ALLAN C. · 2016 to 2018
$747k
Micro-RNA Profiling and Cardiovascular Effects of Traffic Particle ExposureR21ES020010 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BACCARELLI, ANDREA, HOU, LIFANG · 2011 to 2012
$443k
NCI NIH HHS P30 CA060553NHLBI NIH HHS T32 HL007118NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES023450NIEHS NIH HHS R01 ES014663NIEHS NIH HHS R01 ES015172NIEHS NIH HHS R01 ES021733NIEHS NIH HHS R01 ES025225NIEHS NIH HHS R21 ES020010
6 · The paper itself

Abstract

backgroundLong-term PM

objectiveWe assessed the relationship of major PM

methodsThis analysis included 552 participants from the Normative Aging Study with multiple visits between 2000 and 2011 (n=940 visits). We estimated 1-year PM

resultsSulfate and ammonium were selected by the LASSO in the Horvath DNAm-age models. In a fully-adjusted multiple-species model, interquartile range increases in both 1-year sulfate (95%CI: 0.28, 0.74, P<0.0001) and ammonium (95%CI: 0.02, 0.70, P=0.04) levels were associated with at least a 0.36-year increase in Horvath DNAm-age. No PM

conclusionOur results demonstrate that sulfate and ammonium were most associated with Horvath DNAm-age and suggest that DNAm-age measures differ in their sensitivity to ambient particle exposures and potentially disease.

Indexed as

AgedAgingAir PollutantsDNADNA MethylationEnvironmental MonitoringFemaleHumansInhalation ExposureMaleParticle SizeParticulate MatterUnited StatesUnited States Environmental Protection AgencyAir PollutantsDNAParticulate MatterDNA methylation ageEpigeneticsLong-term exposureParticulate matter 2.5

Identifiers

PMID28284819
PMCPMC5396466
OpenAlexW2592092784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.