Evidence map›Paper›PMID 28284256›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2017

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India.

N Shaikh, A Gupte, S Dharmshale, S Pokkali, M Thakar, V J Upadhye, A A Ordonez, A Kinikar, N Gupte, V Mave and 6 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Screening tests for active pulmonary tuberculosis in children.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

N ShaikhNational AIDS Research Institute, Pune, India.
A GupteJohns Hopkins Bloomberg School of Public Health, Baltimore, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
S DharmshaleByramjee Jeejeebhoy Government Medical College, Pune, India.
S PokkaliDepartment of Pediatrics, Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
M ThakarNational AIDS Research Institute, Pune, India.
V J UpadhyeImperial College, London, UK.
A A OrdonezDepartment of Pediatrics, Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
A KinikarByramjee Jeejeebhoy Government Medical College, Pune, India.
N GupteDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, Byramjee Jeejeebhoy Government Medical College, Pune, India.
V MaveDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, Byramjee Jeejeebhoy Government Medical College, Pune, India.
A KagalByramjee Jeejeebhoy Government Medical College, Pune, India.
A GuptaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
A LalvaniImperial College, London, UK.
R ParanjpeNational AIDS Research Institute, Pune, India.
R BharadwajByramjee Jeejeebhoy Government Medical College, Pune, India.
S K JainDepartment of Pediatrics, Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Government Medical College · INJohns Hopkins University · USNational AIDS Research Institute · INGovernment Medical College · INImperial College London · GBJohns Hopkins Medicine · US

Funding

The Johns Hopkins Baltimore-Washington-India Clinical Trials Unit (BWI CTU)UM1AI069465 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Charles W. Flexner, Amita Gupta · 2012 to 2026
$34.1M
Byramee Jeejeebhoy Medical College (BJMC), Pune, India: Clinical Trials UnitU01AI069497 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GUPTA, AMITA · 2007 to 2011
$4.1M
Novel imaging biomarkers to address fundamental controversies in TB pathogenesisDP2OD006492 · OD · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2009 to 2014
$2.9M
Diagnosis of active TB in HIV infected and uninfected young children in IndiaR03HD061059 · NICHD · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2009 to 2010
$132k
NIAID NIH HHS U01 AI069497NIAID NIH HHS UM1 AI069465NICHD NIH HHS R03 HD061059NIH HHS DP2 OD006492
6 · The paper itself

Abstract

settingThe tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children.

designChildren (age 5 years) with suspected TB were prospectively screened at a tertiary hospital in Pune, India; the children underwent TST, and standard (early secretory antigenic target 6 and culture filtrate protein 10) and enhanced (five additional novel antigens) enzyme-linked immunospot (ELISpot) assays.

resultsOf 313 children (median age 30 months) enrolled, 92% had received bacille Calmette-Guérin vaccination, 53% were malnourished and 9% were coinfected with the human immunodeficiency virus (HIV); 48 (15%) had TB, 128 (41%) did not, and TB could not be ruled out in 137 (44%). The sensitivity of enhanced (45%) and standard (42%) ELISpot assays for diagnosing TB was better than that of TST (20%) (P  0.03); however, enhanced ELISpot was not more sensitive than the standard ELISpot assay (P = 0.50). The specificity of enhanced ELISpot, standard ELISpot and TST was respectively 82% (95%CI 74-89), 88% (95%CI 81-94) and 98% (95%CI 93-100). Rv3879c and Rv3615c, previously reported to be promising antigens, failed to improve the diagnostic performance of the ELISpot assay.

conclusionThe TST and the standard and novel ELISpot assays performed poorly in diagnosing active TB among young children in India.

Indexed as

Antigens, BacterialBCG VaccineChild, PreschoolCoinfectionEnzyme-Linked Immunospot AssayFemaleHIV InfectionsHumansIndiaInfantInterferon-gamma Release TestsMaleMalnutritionMass ScreeningProspective StudiesSensitivity and SpecificityAntigens, BacterialBCG Vaccine

Identifiers

PMID28284256
PMCPMC5453635
OpenAlexW2611942434

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.