Observational studyBreast cancer research : BCR2017
Anthropometric measures and serum estrogen metabolism in postmenopausal women: the Women's Health Initiative Observational Study.
Observational study in Breast cancer research : BCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- Associations between serum estradiol and estrone and Alzheimer's disease biomarkers: An analysis in female participants from the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study (EPAD LCS).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sex Differences in the Effect of Changes in Body Mass Index on the Risk of Developing Gastric Cancer: Findings from a Nationwide Retrospective Cohort Study.Gut and liver · 2026Article
- Estrogen metabolism-related lifestyle score and risk of postmenopausal breast, endometrial, and ovarian cancers: findings from two large prospective cohort studies.Cancer prevention research (Philadelphia, Pa.) · 2026Article
- Birthweight, height, and body mass index in relation to the expression of stem cell markers among women with benign breast biopsies in the Nurses' Health Study II.British journal of cancer · 2025Article
- Endometrial thickness and pathology in postmenopausal women with bleeding on transdermal 17β-estradiol plus body-identical progesterone.Archives of gynecology and obstetrics · 2025Article
- Age of menopause and dementia risk in 10,832 women from the Swedish Twin Registry.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Anthropometric Measures and Fuchs' Endothelial Corneal Dystrophy: The Women's Health Initiative Observational Study.Investigative ophthalmology & visual science · 2025Observational
- Global, regional, and national burden of ovarian cancer attributable to high body mass index, 1990-2021: insights from the global burden of disease study 2021.Frontiers in oncology · 2025Article
- Metabolic obesity phenotypes and thyroid cancer risk: A systematic exploration of the evidence.Obesity science & practice · 2024Review
- Associations of tubal ligation and hysterectomy with serum androgen and estrogen metabolites among postmenopausal women in the Women's Health Initiative Observational Study.Cancer causes & control : CCC · 2024Observational
- Comparison of leptin and estrone levels between normal body mass index and obese menopausal women.Narra J · 2024Article
- Article
- Among men, androgens are associated with a decrease in Alzheimer's disease risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- The role of obesity in sarcopenia and the optimal body composition to prevent against sarcopenia and obesity.Frontiers in endocrinology · 2023Article
- Sex hormones, body mass index, and related comorbidities associated with developing Sjögren's disease: a nested case-control study.Clinical rheumatology · 2022Article
- Article
- Osteoporosis in nontuberculous mycobacterial pulmonary disease: a cross-sectional study.BMC pulmonary medicine · 2022Article
- A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women.Journal of clinical medicine · 2022Article
- Associations of established breast cancer risk factors with urinary estrogens in postmenopausal women.Cancer causes & control : CCC · 2022Article
- Measured body size and serum estrogen metabolism in postmenopausal women: the Ghana Breast Health Study.Breast cancer research : BCR · 2022Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundSeveral anthropometric measures have been associated with hormone-related cancers. However, it is unknown whether estrogen metabolism plays an important role in these relationships. We examined whether measured current body mass index (BMI), waist-to-hip ratio (WHR), height, and self-reported BMI at age 18 years were associated with serum estrogens/estrogen metabolites using baseline, cross-sectional data from 1835 postmenopausal women enrolled in the Women's Health Initiative Observational Study.
methodsFifteen estrogens/estrogen metabolites were quantified using liquid chromatography-tandem mass spectrometry. Geometric means (GMs) of estrogens/estrogen metabolites (in picomoles per liter) were estimated using inverse probability weighted linear regression, adjusting for potential confounders and stratified on menopausal hormone therapy (MHT) use.
resultsAmong never or former MHT users, current BMI (≥30 vs. <25 kg/m
conclusionsOur data suggest that postmenopausal BMI is associated with increased circulating levels of parent estrogens and reduced methylation of catechol estrogen metabolites, the estrogen metabolism patterns that have previously been associated with higher breast cancer risk.
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