ReviewCurrent opinion in neurobiology2017
Astrocytes and the modulation of sleep.
Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 116 citations in OpenAlex.
- Astrocyte-centered temporal resilience at the brain-behavior-immunity interface: sleep-circadian disruption and perioperative cognitive vulnerability in older adults.Brain, behavior, & immunity - health · 2026Review
- The glymphatic system in sleep: a nexus of waste clearance, brain homeostasis, and disease intervention.Molecular psychiatry · 2026Review
- Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination.Nature communications · 2026Article
- Glymphatic System Dysregulation as a Key Contributor to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.International journal of molecular sciences · 2025Review
- Astrocytes in maintaining neuronal health and brain function: interplay of aging, diet, and environment.Metabolic brain disease · 2025Review
- Cortical astrocyte histamine-1-receptors regulate intracellular calcium and extracellular adenosine dynamics across sleep and wake.PLoS biology · 2025Article
- Astrocytes serve as integrative hubs regulating sleep and arousal.PLoS biology · 2025Article
- Concussion Disrupts Sleep in Adolescents: A Systematic Review and Meta-Analysis.Clocks & sleep · 2025Review
- An integrative analysis of cell-specific transcriptomics and nuclear proteomics of sleep-deprived mouse cerebral cortex.Scientific reports · 2025Article
- Deletion of Clock GeneClocks & sleep · 2025Article
- Astrocytes Regulate Brain State Transitions.Neurochemical research · 2025Review
- Adenosine-Dependent Arousal Induced by Astrocytes in a Brainstem Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer's disease mouse model.Scientific reports · 2024Article
- Resilience Building Practices for Women Physicians.Journal of women's health (2002) · 2024Article
- Sleep, Glial Function, and the Endocannabinoid System: Implications for Neuroinflammation and Sleep Disorders.International journal of molecular sciences · 2024Review
- Article
- VX-765 Alleviates Circadian Rhythm Disorder in a Rodent Model of Traumatic Brain Injury Plus Hemorrhagic Shock and Resuscitation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- Astrocyte regulation of extracellular space parameters across the sleep-wake cycle.Frontiers in cellular neuroscience · 2024Review
- Gene Expression at the Tripartite Synapse: Bridging the Gap Between Neurons and Astrocytes.Advances in neurobiology · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Astrocytes are being identified as having multiple roles in sleep. Initially they were shown to modulate the process of sleep homeostasis through the release of adenosine which acts on adenosine A1 receptors (A1R) to promote sleep drive. More recent studies indicate that the astrocyte also plays pivotal, sleep-dependent roles in 'cleaning the brain' during sleep. This work indicates that a glymphatic pathway that critically relies on astrocytic aquaporin 4, is able to flush solutes from the brain and that deficits in this pathway may contribute to Alzheimer's disease. Finally, astrocytes are known to play important metabolic roles and provide energy on demand to neurons through an astrocyte-neuron shuttle. Given that the time course of astrocytic function is orders of magnitude slower than that of the neuron, this non-neuronal cell is perfectly tuned to modulating slow, state-dependent changes in the brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.