Evidence map›Paper›PMID 28283963›Full record

ReviewCurrent neurology and neuroscience reports2017

The Application of Proteomics to Traumatic Brain and Spinal Cord Injuries.

George Anis Sarkis, Manasi D Mangaonkar, Ahmed Moghieb, Brian Lelling, Michael Guertin, Hamad Yadikar, Zhihui Yang, Firas Kobeissy, Kevin K W Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Glycosylation Changes in Brain Cancer.ACS chemical neuroscience · 2018
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

George Anis SarkisProgram for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.
Manasi D MangaonkarProgram for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.
Ahmed MoghiebProgram for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.
Brian LellingDepartment of Chemistry, University of Florida, Gainesville, FL, 32611, USA.
Michael GuertinDepartment of Chemistry, University of Florida, Gainesville, FL, 32611, USA.
Hamad YadikarProgram for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.
Zhihui YangProgram for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.
Firas KobeissyProgram for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.
Kevin K W WangProgram for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA. kawangwang17@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) and traumatic spinal cord injury (SCI), collectively termed neurotrauma, are two parallel neurological conditions that can cause long-lasting neurological impairment and other comorbidities in patients, while at the same time, can create a high burden to society. To date, there are still no FDA-approved therapeutic interventions for either TBI or SCI. Recent advances in proteomic technologies, including tandem mass spectrometry, as well as imaging mass spectrometry, have enabled new approaches to study the differential proteome in TBI and SCI with the use of either animal disease models and/or biosamples from clinical observational studies. Thus, the applications of state-of-the-art proteomic method hold promises in shedding light on identifying clinically useful neurotrauma "biomarkers" and/or in identifying distinct and, otherwise, unobvious systems pathways or "key drivers" that can be further exploited as new therapeutic intervention targets.

Indexed as

ProteomicsAnimalsBiomarkersBrainBrain InjuriesComorbidityDisease Models, AnimalHumansMass SpectrometrySpinal Cord InjuriesBiomarkersMass spectrometryMass spectrometry imagingSpinal cord injury neuroproteomicsSystems biologyTraumatic brain injury

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.