ReviewCurrent neurology and neuroscience reports2017
PFO and Migraine: Is There a Role for Closure?
Review in Current neurology and neuroscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- The relationship between anxiety and patent foramen ovale: a preliminary study.BMC psychology · 2026Observational
- Migraine and stroke: correlation, coexistence, dependence - a modern perspective.The journal of headache and pain · 2025Review
- Diagnostic value of contrast-enhanced ultrasonography for patent foramen ovale detection.Journal of thoracic disease · 2024Article
- Short-term efficacy of right-to-left shunt closure in patients with vestibular migraine.Frontiers in neurology · 2024Article
- Percutaneous closure of simple congenital heart diseases under echocardiographic guidance.European journal of medical research · 2023Review
- Comparison of the short-term efficacy of different Amplatzer models and similar occluders in the treatment of patent foramen ovale.Frontiers in cardiovascular medicine · 2023Article
- Heart-brain axis: Association of congenital heart abnormality and brain diseases.Frontiers in cardiovascular medicine · 2023Review
- Case report: Anxiety and depression as initial symptoms in a patient with acute hypoxia and patent foramen ovale.Frontiers in psychiatry · 2023Article
- Clinical features andZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- The Relationship Between Patent Foramen Ovale and Unexplained Dizziness: A Prospective Analysis in China.Neuropsychiatric disease and treatment · 2022Article
- Characteristics of Patent Foramen Ovale: Analysis from a Single Center.Cardiology research and practice · 2022Article
- Patent Foramen Ovale-A Not So Innocuous Septal Atrial Defect in Adults.Journal of cardiovascular development and disease · 2021Review
- A review of diving practices and outcomes following the diagnosis of a persistent (patent) foramen ovale in compressed air divers with a documented episode of decompression sickness.Diving and hyperbaric medicine · 2020Review
- Device closure for patent foramen ovale in patients with cryptogenic stroke: which patients should get it?European heart journal supplements : journal of the European Society of Cardiology · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Observational studies suggest that closure of a patent foramen ovale for other indications may reduce or even eliminate migraine attacks, particularly migraine with aura. The first randomized clinical trial of patent foramen ovale (PFO) closure for prevention of migraine, the MIST trial, showed negative results. The results of the other two completed studies in this area have recently been published in the last year. PRIMA and PREMIUM were also both negative for their primary endpoints. The PREMIUM trial did show a reduction in headache days in the migraine with aura subgroup but the final results of this subset analysis have not been published. There may be an as yet undetermined subgroup of patients with migraine who would benefit from closure, but slow recruitment has been a barrier to further study. Several potentially life-threatening procedure-related adverse events occurred in the clinical trials. At this time, we recommend against offering PFO closure as a preventive treatment for migraine. Based on available observational data, patients for whom PFO closure is indicated for other reasons may see some improvement in their migraines.
Indexed as
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Registered trials
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