ReviewCurrent neurology and neuroscience reports2017
Migraine and Stroke: What's the Link? What to Do?
Review in Current neurology and neuroscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Migraine and pregnancy-related headaches as a risk factor for cardiovascular and cerebrovascular events in pregnancy: a systematic review and meta-analysis of over 94 million pregnancies.The journal of headache and pain · 2025Pooled it
- Ultrasonic assessment of carotid intima-media thickness in migraine: a meta-analysis.The Journal of international medical research · 2019Pooled it
- Migraine in Young Stroke Patients-Better Outcomes Despite Distinct Risk Profiles: Insights From the STROKE-CARD-Study.European journal of neurology · 2026Observational
- Prognostic Significance ofNeurology. Genetics · 2026Article
- Assessing Blood Pressure Effects of Anti-CGRP Antibody Treatment in Migraine: A Retrospective Real-World Analysis.Biomedicines · 2025Article
- Migraine and stroke: correlation, coexistence, dependence - a modern perspective.The journal of headache and pain · 2025Review
- Reviewing migraine-associated pathophysiology and its impact on elevated stroke risk.Frontiers in neurology · 2024Review
- Migrainous stroke in a male patient with familial hemiplegic migraine.Archives of medical science : AMS · 2024Article
- Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review.Frontiers in neuroscience · 2024Review
- Review
- Article
- Recurrent migraine with binocular transient vision loss associated with acute stroke: A case report.Annals of medicine and surgery (2012) · 2021Article
- Acute Migraine Prescription Patterns Vary by Baseline Cardiovascular Risk and Clinical Characteristics: A Real-World Evidence Study.Pain and therapy · 2020Article
- Evaluation of retinal vessel density and choriocapillaris flow in migraine patients with and without aura.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Migrainous Infarction and Cortical Spreading Depression.Discoveries (Craiova, Romania) · 2020Review
- Deep Phenotyping of Headache in Hospitalized COVID-19 PatientsFrontiers in neurology · 2020Article
- Remote poststroke headache in children: Characteristics and association with stroke recurrence.Neurology. Clinical practice · 2019Article
- Aura and Stroke: relationship and what we have learnt from preclinical models.The journal of headache and pain · 2019Review
- Risk of ischaemic stroke in patients with migraine: a longitudinal follow-up study using a national sample cohort in South Korea.BMJ open · 2019Article
- Foveal and Peripapillary Vascular Decrement in Migraine With Aura Demonstrated by Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine and stroke are common, disabling neurologic disorders, with a high socioeconomic burden. A link between them has been proposed years ago, and various theories have been proposed to explain this bidirectional relation. However, the precise causes remain unclear. We briefly summarize existing hypotheses of this correlation seeking for recommendations for stroke prevention in migraineurs, if any exist. Among the strongest suggested theories of migraine-stroke association are cortical spreading depression, endovascular dysfunction, vasoconstriction, neurogenic inflammation, hypercoagulability, increased prevalence of vascular risk factors, shared genetic defects, cervical artery dissection, and patent foramen ovale. There is no evidence that any preventive therapy in migraineurs should be used to decrease stroke risk, even in most predisposed subset of patients. However, a woman with migraine with aura should be encouraged to cease smoking and avoid taking oral contraceptives with high estrogen doses. We need further investigation to better understand the complexity of migraine-stroke association and to make firm recommendations for the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.