Evidence map›Paper›PMID 28283857›Full record

ArticleJournal of abnormal child psychology2018

Gene-Environment Interactions in ADHD: The Roles of SES and Chaos.

Karen L Gould, William L Coventry, Richard K Olson, Brian Byrne

Abstract readTwin Study
PubMed Publisher
In one paragraph

Article in Journal of abnormal child psychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  11. A Potential Role for Neuroinflammation in ADHD.Advances in experimental medicine and biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karen L GouldDiscipline of Psychology, University of New England, Armidale, NSW, 2351, Australia.
William L CoventryDiscipline of Psychology, University of New England, Armidale, NSW, 2351, Australia. william.coventry@une.edu.au.
Richard K OlsonUniversity of Colorado, Boulder, Boulder, CO, 80309-0345, USA.
Brian ByrneDiscipline of Psychology, University of New England, Armidale, NSW, 2351, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although attention-deficit/hyperactivity disorder (ADHD) is highly heritable, emerging evidence suggests symptoms are associated with interactions between genes and the environment (GxE) during development. This study tested whether heritability of ADHD symptoms is moderated by two environmental factors: socioeconomic status (SES) and chaos (household disorganisation). A population sample of 520 twin pairs (N = 1040, 52.3% female) from 6 to 15 years completed measures of behavior and home environment. Structural equation modelling was then used to test whether environmental factors were associated with a change in the extent to which genes explain variability in ADHD symptoms. Neither chaos nor SES moderated heritability, with consistent contributions from both genes and environment indicated across socioeconomic strata and levels of chaos. This finding contrasts with those of previous research, underlining the need to replicate results in the emerging field of GxE research across different populations and statistical methods. Robust findings may assist in developing targeted interventions for genetically vulnerable individuals.

Indexed as

FamilyGene-Environment InteractionSocial ClassAdolescentAttention Deficit Disorder with HyperactivityAustraliaChildFemaleHumansMaleAttention-deficit hyperactivity disorderBehavior geneticsChaosGene x environment interaction

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.