Evidence map›Paper›PMID 28283851›Full record

ArticleClinical and experimental nephrology2017

Serum ferritin as an indicator of the development of encephalopathy in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome.

Masaki Shimizu, Natsumi Inoue, Mondo Kuroda, Hitoshi Irabu, Maiko Takakura, Hisashi Kaneda, Naotoshi Sugimoto, Kazuhide Ohta, Akihiro Yachie

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Article in Clinical and experimental nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Masaki ShimizuDepartment of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan. shimizum@staff.kanazawa-u.ac.jp.ORCID http://orcid.org/0000-0003-1077-7772
Natsumi InoueDepartment of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Mondo KurodaDepartment of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Hitoshi IrabuDepartment of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Maiko TakakuraDepartment of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Hisashi KanedaDepartment of Pediatrics, Komatsu Municipal Hospital, Komatsu, Japan.
Naotoshi SugimotoDepartment of Physiology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Kazuhide OhtaDepartment of Pediatrics, Kanazawa Medical Center, Kanazawa, Japan.
Akihiro YachieDepartment of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Kanazawa University · JPKanazawa Medical Center · JPKomatsu (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the diagnostic value of serum ferritin levels as a marker of disease activity and the development of encephalopathy in hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli.

methodsTwenty patients with HUS were studied. Serum ferritin levels were compared with clinical features and serum soluble tumor necrosis factor receptor (sTNFR) I and sTNFRII levels. Serum sTNFRI and sTNFRII levels were quantified by enzyme-linked immunosorbent assays.

resultsSerum ferritin levels were significantly elevated at the time of the diagnosis of HUS. Serum ferritin levels were significantly elevated in patients with encephalopathy compared to patients without encephalopathy. HUS patients with serum ferritin levels of >687.5 ng/ml were at high risk of encephalopathy. Serum ferritin levels were significantly positively correlated with serum sTNFRI and sTNFRII levels.

conclusionsSerum ferritin levels are a promising indicator of the development of encephalopathy in HUS.

Indexed as

AdolescentAdultBiomarkersBrain DiseasesChildChild, PreschoolEnterohemorrhagic Escherichia coliEscherichia coli InfectionsFemaleFerritinsHemolytic-Uremic SyndromeHumansInfantMaleReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIBiomarkersFerritinsReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIEncephalopathyEnterohemorrhagic Escherichia coliFerritinHemolytic uremic syndrome

Identifiers

PMID28283851
OpenAlexW2593799705

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.