Evidence map›Paper›PMID 28283840›Full record

SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2017

Locking stand-alone cages versus anterior plate constructs in single-level fusion for degenerative cervical disease: a systematic review and meta-analysis.

Mithun Nambiar, Kevin Phan, John Edward Cunningham, Yi Yang, Peter Lawrence Turner, Ralph Mobbs

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04547959 (Prospective Clinical Study to Evaluate the Efficacy of the Stand-alone Cervical Interbody Cage C-CURVE), which is not on this map. Cited by 34 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04547959 nacompletednot on this mapstarted 2020, after this paper: background citation

Prospective Clinical Study to Evaluate the Efficacy of the Stand-alone Cervical Interbody Cage C-CURVE (Titanium) Manufactured by MEDICREA®

TypeinterventionalSponsorMedicrea InternationalRan2020 to 2024Enrolled82ConditionsC-CURVE , Cervical Interbody Cage, Cervical Disc Disease, Cervical DiscopathyArmscervical interbody cage C-CURVE
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  4. Locking stand-alone cage versus anterior plate construct in anterior cervical discectomy and fusion: a systematic review and meta-analysis based on randomized controlled trials.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020
    Pooled it
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  6. Clinical outcomes of locking stand-alone cage versus anterior plate construct in two-level anterior cervical discectomy and fusion: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019
    Pooled it
  7. Two-level ACDF with a zero-profile stand-alone spacer compared to conventional plating: a prospective randomized single-center study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mithun NambiarDepartment of Orthopaedics, The Royal Melbourne Hospital, Grattan Street, Melbourne, VIC, 3050, Australia. mithunnambiar1@gmail.com.
Kevin PhanNeuro Spine Surgery Research Group, Prince of Wales Private Hospital, Randwick, NSW, 2031, Australia.
John Edward CunninghamDepartment of Orthopaedics, The Royal Melbourne Hospital, Grattan Street, Melbourne, VIC, 3050, Australia.
Yi YangDepartment of Orthopaedics, The Royal Melbourne Hospital, Grattan Street, Melbourne, VIC, 3050, Australia.
Peter Lawrence TurnerDepartment of Orthopaedics, The Royal Melbourne Hospital, Grattan Street, Melbourne, VIC, 3050, Australia.
Ralph MobbsNeuro Spine Surgery Research Group, Prince of Wales Private Hospital, Randwick, NSW, 2031, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo conduct a meta-analysis to compare the clinical and radiological outcomes in single-level anterior cervical discectomy and fusion (ACDF) surgery for degenerative cervical disease performed by either single-level locking stand-alone cage (LSC) or anterior plate construct (APC).

methodsWe performed a comprehensive database search of Medline, PubMed, EMBASE and Cochrane Database of Systematic Reviews according to PRISMA guidelines and identified six articles that satisfied our inclusion criteria. We excluded all non-English language articles and articles which did not directly compare LSC and APC. Only papers which focussed on single-level ACDF were included in the study.

resultsThere were no significant differences in blood loss, clinical outcomes (JOA, VAS, NDI scores) or radiological outcomes (cervical lordosis, segmental Cobb angle, subsidence and fusion) between the two groups. Operative time was significantly shorter in the LSC group (MD 7.2 min, 95% CI 0.3-14.1, p = 0.04). APC was associated with a statistically significant increase in dysphagia in the follow-up period (OR 6.2, 95% CI 1.0-36.6, p = 0.05).

conclusionLSC and APC have similar clinical and radiological outcomes. Further blinded randomised trials are required to establish conclusive evidence in favour of LSC with regards to minimising post-operative dysphagia. We also encourage future studies to make use of formalised dysphagia outcome measures in reporting complications.

Indexed as

Bone PlatesInternal FixatorsBlood Loss, SurgicalCervical VertebraeDeglutition DisordersDiskectomyHumansIntervertebral Disc DegenerationLordosisNeckOperative TimeRadiographyRetrospective StudiesSpinal FusionACDFCervicalPlateStand-aloneZero-profile

Identifiers

PMID28283840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.