SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2017
The effect of NSAIDs on spinal fusion: a cross-disciplinary review of biochemical, animal, and human studies.
Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- The analgesic effect and safety of preoperative versus postoperative administration of celecoxib in patients who underwent arthroscopic rotator cuff repair: a randomized, controlled study.Inflammopharmacology · 2022Trial
- Life satisfaction and pain interference in spine surgery patients before and after surgery: comparison between on-opioid and opioid-naïve patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Trial
- An Update on Pain Management in Pediatric Spine Surgery.Current reviews in musculoskeletal medicine · 2026Review
- Bone Fusion in the Cervical Spine: Where Are We Now?Bioengineering (Basel, Switzerland) · 2026Review
- The Impact of Proton Pump Inhibitors on Pseudarthrosis Rates Following Multi-Level Lumbar Fusion.Spine surgery and related research · 2026Article
- Do Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Adversely Impact Fracture Healing? A Critical Review of the Literature.Current reviews in musculoskeletal medicine · 2025Review
- Effect of Postoperative Nonsteroidal Anti-Inflammatory Drug Use on Surgical Outcomes in Multi- and Single-Level Posterior Cervical Fusions.Spine surgery and related research · 2025Article
- Effect of post-operative NSAID use on rotator cuff repair outcomes.Journal of orthopaedics · 2024Article
- The Effect of Nonsteroidal Anti-inflammatory Drugs on Union Rates Following Joint Arthrodesis: A Meta-Analysis.Cureus · 2024Review
- Effectiveness of Corticosteroid Therapy in Enhancing Early Postoperative Recovery in Lumbar Spinal Stenosis Patients: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Perioperative pain protocols following surgery for adolescent idiopathic scoliosis: a snapshot of current treatments utilized by attending orthopedic surgeons.Spine deformity · 2024Article
- Osteoimmunology: Interactions With the Immune System in Spinal Fusion.International journal of spine surgery · 2023Article
- Republication of "How Will the Foot and Ankle Orthopedic Community Respond to the Growing Opioid Epidemic?"Foot & ankle orthopaedics · 2023Review
- Neurosurgical management of vertebral lesions in pediatric chronic recurrent multifocal osteomyelitis: patient series.Journal of neurosurgery. Case lessons · 2023Article
- Nonsteroidal anti-inflammatory drugs (NSAID) do not increase blood loss or the incidence of postoperative epidural hematomas when using minimally invasive fusion techniques in the degenerative lumbar spine.Frontiers in surgery · 2022Article
- Postoperative Pain Management in Enhanced Recovery Pathways.Journal of pain research · 2022Review
- The Impact of Perioperative Multimodal Pain Management on Postoperative Outcomes in Patients (Aged 75 and Older) Undergoing Short-Segment Lumbar Fusion Surgery.Pain research & management · 2022Article
- Parecoxib Reduced Postsurgical Pain and Facilitated Movement More Than Patient Controlled Analgesia.Frontiers in surgery · 2022Article
- Best Practices for Postoperative Management of Posterior Sacroiliac Joint Fusion.Journal of pain research · 2022Review
- The effect of non-steroidal anti-inflammatory medications on spinal fracture healing: a systematic review.Journal of spine surgery (Hong Kong) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNon-steroidal anti-inflammatory drugs (NSAIDs) play an important role in postoperative pain management. However, their use in the setting of spine fusion surgery setting has long been a topic of controversy. In this review we examined relevant research, including in vivo, animal, and clinical human studies, with the aim of understanding the effect of NSAIDs on spinal fusion. STUDY DESIGN/
settingSystematic review of study designs of all types from randomized controlled trials and meta-analyses to single-institution retrospective reviews.
methodsA search of PubMed and Embase was conducted using the keywords: "spine," "spinal fracture," NSAIDs, anti-inflammatory non-steroidal agents, bone, bone healing, fracture, fracture healing, yielding a total of 110 studies. Other 28 studies were identified by cross-referencing, resulting in total 138 studies.
resultsThere is no level I evidence from human studies regarding the use of NSAIDs on spinal fusion rates. The overall tone of the spine literature in the early 2000s was that NSAIDs increased the rate of non-union; however, nearly all human studies published after 2005 suggest that short-term (<2 weeks) postoperative use have no such effect. The dose dependency that is seen with a 2-week postoperative course is not present when NSAIDs are only used for 48 h after surgery.
conclusionsNSAID appear to have dose-dependent and duration-dependent effects on fusion rates. The short-term use of low-dose NSAIDs around the time of spinal fusion surgery is reasonable. Spine surgeons can consider the incorporation of NSAIDs into pain control regimens for spinal fusion patients with the goal of improving pain control and reducing the costs and complications associated with opioids.
Indexed as
Identifiers
28283838What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.