Evidence map›Paper›PMID 28283834›Full record

ArticleEuropean child & adolescent psychiatry2017

Risk factors for comorbid oppositional defiant disorder in attention-deficit/hyperactivity disorder.

Siri D S Noordermeer, Marjolein Luman, Wouter D Weeda, Jan K Buitelaar, Jennifer S Richards, Catharina A Hartman, Pieter J Hoekstra, Barbara Franke, Dirk J Heslenfeld, Jaap Oosterlaan

Open access · hybridAbstract read
In one paragraph

Article in European child & adolescent psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Exploring Transdiagnostic Mechanisms of Youth Externalizing Psychopathology: A Longitudinal Person-Centered Approach.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  5. Developmental Pathways of Inattention, Hyperactivity/Impulsivity, and Disruptive Behaviors: A Longitudinal, Person-Centered Approach.Clinical psychological science : a journal of the Association for Psychological Science · 2025
    Article
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Siri D S NoordermeerClinical Neuropsychology Section, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands. s.d.s.noordermeer@vu.nl.
Marjolein LumanClinical Neuropsychology Section, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Wouter D WeedaLeiden University, Leiden, The Netherlands.
Jan K BuitelaarRadboud University Medical Center, Nijmegen, The Netherlands.
Jennifer S RichardsRadboud University Medical Center, Nijmegen, The Netherlands.
Catharina A HartmanUniversity of Groningen, Groningen, The Netherlands.
Pieter J HoekstraUniversity of Groningen, Groningen, The Netherlands.
Barbara FrankeRadboud University Medical Center, Nijmegen, The Netherlands.
Dirk J HeslenfeldClinical Neuropsychology Section, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Jaap OosterlaanClinical Neuropsychology Section, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Vrije Universiteit Amsterdam · NLRadboud University Nijmegen · NLUniversity of Groningen · NLDutch Expert Centre for Screening · NLLeiden University · NL

Funding

International Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2M
European Union 7th Framework programs AGGRESSOTYPE 602805National Institutes of Health R01MH62873NIMH NIH HHS R01 MH062873NWO Brain and Cognition 056 24 011NWO Investment Grant 1750102007010
6 · The paper itself

Abstract

Oppositional defiant disorder (ODD) is highly prevalent in attention-deficit/hyperactivity disorder (ADHD). Individuals with both ADHD and ODD (ADHD + ODD) show a considerably worse prognosis compared with individuals with either ADHD or ODD. Therefore, identification of risk factors for ADHD + ODD is essential and may contribute to the development of (early) preventive interventions. Participants were matched for age, gender, and ADHD-subtype (diagnostic groups), and did not differ in IQ. Predictors included pre- and perinatal risk factors (pregnancy duration, birth weight, maternal smoking during pregnancy), transgenerational factors (parental ADHD; parental warmth and criticism in diagnostic groups), and postnatal risk factors (parental socioeconomic status [SES], adverse life events, deviant peer affiliation). Three models were assessed, investigating risk factors for ADHD-only versus controls (N = 86), ADHD + ODD versus controls (N = 86), and ADHD + ODD versus ADHD-only (N = 90). Adverse life events and parental ADHD were risk factors for both ADHD + ODD and ADHD-only, and more adverse life events were an even stronger risk factor for comorbid ODD compared with ADHD-only. For ADHD + ODD, but not ADHD-only, parental criticism, deviant peer affiliation, and parental SES acted as risk factors. Maternal smoking during pregnancy acted as minor risk factor for ADHD-only, while higher birth weight acted as minor risk factor for ADHD + ODD. No effects of age were present. Findings emphasise the importance of these factors in the development of comorbid ODD. The identified risk factors may prove to be essential in preventive interventions for comorbid ODD in ADHD, highlighting the need for parent-focused interventions to take these factors into account.

Indexed as

AdolescentAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityComorbidityFemaleHumansMalePrevalenceRisk FactorsADHDComorbidityODDRisk factors

Identifiers

PMID28283834
PMCPMC5610221
OpenAlexW2592234446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.