Evidence map›Paper›PMID 28283823›Full record

Trial reportEuropean journal of nutrition2018

Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial.

Marshall G Miller, Derek A Hamilton, James A Joseph, Barbara Shukitt-Hale

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 93 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 14 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04049162 nacompletednot on this mapstarted 2019, after this paper: background citation

Effects of Blueberry Consumption on Vascular Function, Physical Activity, and Cognition in Sedentary Older Adults

TypeinterventionalSponsorDuke UniversityRan2019 to 2022Enrolled84ConditionsSedentary Lifestyle, Blood Pressure, Arterial Stiffness, Overweight and ObesityArmsBlueberry Plus Exercise (BB-EX), Blueberry Placebo Plus Exercise (P-EX)
NCT05172128 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Blueberry Supplementation on Alzheimer's Biomarkers

TypeinterventionalSponsorDuke UniversityRan2022 to 2023Enrolled12ConditionsMild Cognitive Impairment, Alzheimer DiseaseArmslyophilized blueberry supplement
NCT06735651 narecruitingnot on this mapstarted 2024, after this paper: background citation

Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Female Adults With Prediabetes.

TypeinterventionalSponsorGeorgia State UniversityRan2024 to 2026Enrolled30ConditionsPrediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia)ArmsWild Blueberry, Placebo
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 14 syntheses or guidelines pooled it, 182 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Dietary Flavonoids and Human Cognition: A Meta-Analysis.Molecular nutrition & food research · 2022
    Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Marshall G MillerUSDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA.
Derek A HamiltonDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
James A JosephUSDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA.
Barbara Shukitt-HaleUSDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA. barbara.shukitthale@ars.usda.gov.
Tufts University · USUniversity of New Mexico · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAs populations shift to include a larger proportion of older adults, the necessity of research targeting older populations is becoming increasingly apparent. Dietary interventions with blueberry have been associated with positive outcomes in cell and rodent models of aging. We hypothesized that dietary blueberry would improve mobility and cognition among older adults.

methodsIn this study, 13 men and 24 women, between the ages of 60 and 75 years, were recruited into a randomized, double-blind, placebo-controlled trial in which they consumed either freeze-dried blueberry (24 g/day, equivalent to 1 cup of fresh blueberries) or a blueberry placebo for 90 days. Participants completed a battery of balance, gait, and cognitive tests at baseline and again at 45 and 90 days of intervention.

resultsSignificant supplement group by study visit interactions were observed on tests of executive function. Participants in the blueberry group showed significantly fewer repetition errors in the California Verbal Learning test (p = 0.031, η

conclusionsThese findings show that the addition of easily achievable quantities of blueberry to the diets of older adults can improve some aspects of cognition.

Indexed as

Blueberry PlantsCognitionElder Nutritional Physiological PhenomenaFood, PreservedFruitFunctional FoodAgedCognitive DysfunctionDouble-Blind MethodExecutive FunctionFemaleFreeze DryingGaitGait Disorders, NeurologicHumansMaleAgingBlueberryCognitionGaitPostural Sway

Identifiers

PMID28283823
OpenAlexW2592592425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.