ArticleThe Journal of cell biology1988
Genomic organization and biosynthesis of secreted and cytoplasmic forms of gelsolin.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 163 citations in OpenAlex.
- The therapeutic potential of gelsolin in attenuating cytokine storm, ARDS, and ALI in severe COVID-19.Frontiers in pharmacology · 2024Review
- Loss of secreted gelsolin enhances response to anticancer therapies.Journal for immunotherapy of cancer · 2022Article
- Article
- Plasma Gelsolin Reinforces the Diagnostic Value of FGF-21 and GDF-15 for Mitochondrial Disorders.International journal of molecular sciences · 2021Article
- Regulation of Mitochondrial Function by the Actin Cytoskeleton.Frontiers in cell and developmental biology · 2021Review
- Hypogelsolinemia in Patients Diagnosed with Acute Myeloid Leukemia at Initial Stage of Sepsis.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Cytoskeletal Regulation of Oligodendrocyte Differentiation and Myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Overexpression of GSN could decrease inflammation and apoptosis in EAE and may enhance vitamin D therapy on EAE/MS.Scientific reports · 2017Article
- Involvement of gelsolin in TGF-beta 1 induced epithelial to mesenchymal transition in breast cancer cells.Journal of biomedical science · 2015Article
- Change in blood gelsolin concentration in response to physical exercise.Biology of sport · 2013Article
- Plasma gelsolin levels and outcomes after aneurysmal subarachnoid hemorrhage.Critical care (London, England) · 2013Article
- Gelsolin expression increases β1 -integrin affinity and L1210 cell adhesion.Cytoskeleton (Hoboken, N.J.) · 2013Article
- Serum creatinine as a marker of muscle mass in chronic kidney disease: results of a cross-sectional study and review of literature.Journal of cachexia, sarcopenia and muscle · 2013Article
- Visual insight into how low pH alone can induce actin-severing ability in gelsolin under calcium-free conditions.The Journal of biological chemistry · 2011Article
- Quantitative mass spectrometry-based proteomics reveals the dynamic range of primary mouse astrocyte protein secretion.Journal of proteome research · 2010Article
- Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting.Nature reviews. Drug discovery · 2009Review
- Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease.Molecular neurobiology · 2007Review
- Mini-thin filaments regulated by troponin-tropomyosin.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Gelsolin is a dorsalizing factor in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Gelsolin is an actin regulatory protein which is unique among vertebrates in that it is found as both an intrinsic cytoplasmic protein and as a secreted plasma protein. We demonstrate that plasma and cytoplasmic gelsolins are derived by alternative transcriptional initiation sites and message processing from a single gene 70 kb long, containing at least 14 exons. Their message and amino acid sequences are identical except at the 5' end/NH2 termini. The cytoplasmic-specific 5' sequence is derived from two exons that encode untranslated sequence, while the plasma message-specific 5' sequence is derived from a single exon that encodes untranslated sequence, the signal peptide, and the first 21 residues of the plasma protein. The two transcriptional initiation sites are separated by greater than or equal to 32 kb. Biosynthetic and RNase protection studies indicate that a number of cell types make both plasma and cytoplasmic gelsolin in widely varying amounts and ratios.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.